Latest best seller! Atelocollagen Microsphere

－Microcarriers that have been used for the mass culture of induced pluripotent stem cells and mesenchymal stem cells.－

Atelocollagen microspheres are microbead-like microcarriers for mass cell culture that are made from Atelocollagen, a biomaterial used in regenerative medicine. This product enables high-density mass culture by adhering the culture cells to the surface of approximately 3 million microspheres contained within the product. As demand for mass culture has been increasing, the sale of this product has increased by more than fivefold.

  15mL/bottle　￥31,500（￥34,650 including tax）

 As the Atelocollagen microspheres are produced from only collagen, they can create an in vitro-like environment and are used to expand stem cells while maintaining their undifferentiated potential. These microspheres are sterile, do not require surface treatment, are ready-to-use, and allow cells to be harvested easily by collagenase treatment.

When 1 × 10⁵ adipose-derived stem cells were cultured in a microgravity environment with Atelocollagen microspheres, the cells were observed to be bound to the microspheres. After 14 days of culture, the number of cells grew to approximately 1 × 10⁶. Furthermore, higher expression levels of the stem cell markers OCT4, SOX2, NANOG, and SSEA-3 were observed compared to collagen-coated dish cultures.

 Source：Selective Proliferation of Highly Functional Adipose-Derived Stem Cells in Microgravity Culture with Stirred Microspheres.
Cells. 2021 Mar 4;10(3):560. ©Mashiko T, et al. 2021 (Licensed under CC BY 4.0)

Examples of cell types cultured on Atelocollagen microspheres:

　A list of references can be found on the product page by clicking the button below:

Now, why wouldn’t you try using Atelocollagen Microspheres, which provide easy cell harvesting for the mass culturing of stem cells with maintained undifferentiated potential?