AteloGene® Local Use “Quick Gelation” for in vivo transfection | Koken CO., Ltd.

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AteloGene® Local Use “Quick Gelation”

Outline

Improved gel forming speed and transfection efficiency!!

This in vivo transfection kit is designed for delivering siRNA/miRNA into animal tissues, mouse in particular, to introduce the siRNA/miRNA into cells by local administrations.
Atelocollagen is positively charged and can thus electrostatically form complexes with nucleic acids when they are mixed together at appropriate concentrations and ratios. The complexes protect nucleic acids from being degraded by nucleases in in vivo.

What is Atelocollagen?

Applications

Local administration of nucleic acids

Features

  • Prolonged in vivoRNAi effect because atelocollagen, the main component of AteloGene® products, form complexes with siRNA/miRNA
  • Since AteloGene® products are made from atelocollagen, it is nontoxic.
  • AteloGene® Local Use gelates in the body and siRNA/miRNA are slowly released from the gel at the site of administration.
  • AteloGene® Local Use “Quick Gelation” has been modified to increase in vivo transfection efficiency by focusing on faster gel formation at the site of administration.

Kit contents

① AteloGene® Local Use “Quick Gelation” prefilled syringe
(Including losses during the preparation steps)		 540 μL × 3 syringes
②QG buffer 1.5 mL × 3 tubes*
③2 mL microtube 4 tubes (A spare tube is included)
④18G needle 8 needles (2 spare needles are included)

* The volume and packaging of the QG buffer have been changed. The kit now includes three 1.5mL single-use QG buffer tubes.

Devices and reagents required other than those in the kit

  • 1 mL disposable syringe
  • 27G needle
  • siRNA/miRNA (PAGE- or HPLC-purified grade is recommended.)
  • Container and water for preparation of siRNA/miRNA solution (sterilized, RNase-free)
  • Cooling device (crushed ice, cold block, etc.)
  • Tube rotator (that can tumble and agitate such as TAITEC RT-5, Bibby scientific SB3, etc.)
  • Pipetter and tips (sterilized, RNase-free)
  • High-speed refrigerated centrifuge
  • Anesthetic
Cat. No. Product Package Price

#1492
for Cosmo Bio customers

#1494
for REPROCELL customers

 AteloGene® Local Use
“Quick Gelation”		 1 kit
(15 administrations) *		 Visit distributor’s
web page

*It can be used more than 15 administrations depending on target tissue because one administration is assumed to be 200μl.

Storage: 2-10°C  For research use only.

Click here for frequently asked questions about AteloGene® Local Use
“Quick Gelation”

Experimental example

Local siRNA administration to mouse xenograft model with AteloGene® Local Use “Quick Gelation”.

A remarkable reduction of luciferase expression was observed when a luciferase siRNA (Luc siRNA) was co-administered to dual-luciferase expressing melanoma xenograft mice with AteloGene® Local Use “Quick Gelation”.

Use case

References

  • Cancer
  • Orthopedics
  • Dermatology
  • Cardioangiology
  • Neurology
  • Miscellaneous
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    • LncRNA OTUD6B-AS1 Induces Cisplatin Resistance in Cervical Cancer Cells Through Up-Regulating Cyclin D2 via miR-206.
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    • Depletion of tumor suppressor miRNA-148a in plasma relates to tumor progression and poor outcomes in gastric cancer.
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    • De novo deoxyribonucleotide biosynthesis regulates cell growth and tumor progression in small-cell lung carcinoma.
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    • Pharmacological Inhibition of miR-130 Family Suppresses Bladder Tumor Growth by Targeting Various Oncogenic Pathways via PTPN1.
      Monoe Y, Jingushi K, Kawase A, Hirono T, Hirose R, Nakatsuji Y, Kitae K, Ueda Y, Hase H, Abe Y, Adachi J, Tomonaga T, Tsujikawa K.
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    • Theranostic application of miR-429 in HER2+ breast cancer.
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      HT-29細胞およびSW480細胞（大腸がん細胞）の皮下腫瘍モデルマウスへのsiRNA局所投与。
    • miR-1293, a Candidate for miRNA-Based Cancer Therapeutics, Simultaneously Targets BRD4 and the DNA Repair Pathway.
      Takagawa Y, Gen Y, Muramatsu T, Tanimoto K, Inoue J, Harada H, Inazawa J.
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    • MiR-1 Suppresses Proliferation of Osteosarcoma Cells by Up-regulating p21 via PAX3.
      Fujii R, Osaka E, Sato K, Tokuhashi Y.
      Cancer Genomics Proteomics. 2019 Jan-Feb;16(1):71-79. PMID: 30587501
    • TWEAK/Fn14 Interaction Confers Aggressive Properties to Cutaneous Squamous Cell Carcinoma.
      Hu G, Liang L, Liu Y, Liu J, Tan X, Xu M, Peng L, Zhai S, Li Q, Chu Z, Zeng W, Xia Y.
      J Invest Dermatol. 2019 Apr;139(4):796-806. PMID: 30414907
    • Augmented antitumor activity of 5-fluorouracil by double knockdown of MDM4 and MDM2 in colon and gastric cancer cells.
      Imanishi M, Yamamoto Y, Wang X, Sugaya A, Hirose M, Endo S, Natori Y, Yamato K, Hyodo I.
      Cancer Sci. 2019 Feb;110(2):639-649. PMID: 30488540.
    • Integrin α6β4-Src-AKT signaling induces cellular senescence by counteracting apoptosis in irradiated tumor cells and tissues.
      Jung SH, Lee M, Park HA, Lee HC, Kang D, Hwang HJ, Park C, Yu DM, Jung YR, Hong MN, Kim YN, Park HJ, Ko YG, Lee JS.
      Cell Death Differ. 2019 Jan;26(2):245-259. PMID: 29786073
    • Low levels of tumour suppressor miR-655 in plasma contribute to lymphatic progression and poor outcomes in oesophageal squamous cell carcinoma.
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    • Absence of Cytosolic 2-Cys Prx Subtypes I and II Exacerbates TNF-α-Induced Apoptosis via Different Routes.
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    • Cadherin 11 Inhibition Downregulates β-catenin, Deactivates the Canonical WNT Signalling Pathway and Suppresses the Cancer Stem Cell-Like Phenotype of Triple Negative Breast Cancer.
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      J Clin Med. 2019 Jan 27;8(2). pii: E148. PMID: 30691241
    • MicroRNA-215-5p Treatment Suppresses Mesothelioma Progression via the MDM2-p53-Signaling Axis.
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      Zou XY, Ding D, Zhan N, Liu XM, Pan C, Xia YM.
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      Deng Q, Li KY, Chen H, Dai JH, Zhai YY, Wang Q, Li N, Wang YP, Han ZG.
      Hepatology. 2014 Feb;59(2):518-30. PMID: 23929653
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      Gastroenterology. 2014 Jan;146(1):268-77.e18. PMID: 24120476
    • Guanine nucleotide-binding protein 1 is one of the key molecules contributing to cancer cell radioresistance.
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      Cancer Sci. 2014 Oct;105(10):1351-9. PMID: 25098609
    • Paired box 2 upregulates androgen receptor gene expression in androgen-independent prostate cancer.
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      FEBS J. 2014 Oct;281(19):4506-18. PMID: 25132193
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      Jin J, Ryu HS, Lee KB, Jang JJ.
      PLoS One. 2014 Feb 28;9(2):e90247. PMID: 24587299
    • Significant involvement of herpesvirus entry mediator in human esophageal squamous cell carcinoma.
      Migita K, Sho M, Shimada K, Yasuda S, Yamato I, Takayama T, Matsumoto S, Wakatsuki K, Hotta K, Tanaka T, Ito M, Konishi N, Nakajima Y.
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