AteloGene® Local Use “Quick Gelation” for in vivo transfection | Koken CO., Ltd.

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AteloGene® Local Use “Quick Gelation”

Outline

Improved gel forming speed and transfection efficiency!!

This in vivo transfection kit is designed for delivering siRNA/miRNA into animal tissues, mouse in particular, to introduce the siRNA/miRNA into cells by local administrations.
Atelocollagen is positively charged and can thus electrostatically form complexes with nucleic acids when they are mixed together at appropriate concentrations and ratios. The complexes protect nucleic acids from being degraded by nucleases in in vivo.

What is Atelocollagen?

Applications

Local administration of nucleic acids

Features

  • Prolonged in vivoRNAi effect because atelocollagen, the main component of AteloGene® products, form complexes with siRNA/miRNA
  • Since AteloGene® products are made from atelocollagen, it is nontoxic.
  • AteloGene® Local Use gelates in the body and siRNA/miRNA are slowly released from the gel at the site of administration.
  • AteloGene® Local Use “Quick Gelation” has been modified to increase in vivo transfection efficiency by focusing on faster gel formation at the site of administration.

Kit contents

① AteloGene® Local Use “Quick Gelation” prefilled syringe
(Including losses during the preparation steps)		 540 μL × 3 syringes
②QG buffer 1.5 mL × 3 tubes*
③2 mL microtube 4 tubes (A spare tube is included)
④18G needle 8 needles (2 spare needles are included)

* The volume and packaging of the QG buffer have been changed. The kit now includes three 1.5mL single-use QG buffer tubes.

Devices and reagents required other than those in the kit

  • 1 mL disposable syringe
  • 27G needle
  • siRNA/miRNA (PAGE- or HPLC-purified grade is recommended.)
  • Container and water for preparation of siRNA/miRNA solution (sterilized, RNase-free)
  • Cooling device (crushed ice, cold block, etc.)
  • Tube rotator (that can tumble and agitate such as TAITEC RT-5, Bibby scientific SB3, etc.)
  • Pipetter and tips (sterilized, RNase-free)
  • High-speed refrigerated centrifuge
  • Anesthetic
Cat. No. Product Package Price

#1492
for Cosmo Bio customers

#1494
for REPROCELL customers

 AteloGene® Local Use
“Quick Gelation”		 1 kit
(15 administrations) *		 Visit distributor’s
web page

*It can be used more than 15 administrations depending on target tissue because one administration is assumed to be 200μl.

Storage: 2-10°C  For research use only.

Click here for frequently asked questions about AteloGene® Local Use
“Quick Gelation”

Experimental example

Local siRNA administration to mouse xenograft model with AteloGene® Local Use “Quick Gelation”.

A remarkable reduction of luciferase expression was observed when a luciferase siRNA (Luc siRNA) was co-administered to dual-luciferase expressing melanoma xenograft mice with AteloGene® Local Use “Quick Gelation”.

Use case

References

  • Cancer
  • Orthopedics
  • Dermatology
  • Cardioangiology
  • Neurology
  • Miscellaneous
    • Low blood level of tumour suppressor miR-5193 as a target of immunotherapy to PD-L1 in gastric cancer.
      Kamiya H, Komatsu S, Takashima Y, Ishida R, Arakawa H, Nishibeppu K, Kiuchi J, Imamura T, Ohashi T, Shimizu H, Arita T, Konishi H, Shiozaki A, Kubota T, Fujiwara H, Yagyu S, Iehara T, Otsuji E.
      Br J Cancer. 2024 Mar;130(4):671-681. PMID: 38148376.
    • MiR-140-3p Improves Sensitivity to Docetaxel by Suppressing PD-L1/ABCG2/MVP Expression in Lung Adenocarcinoma.
      Kwon M, Lim D, Park J, Gil W, Jung J, Jung S, Kim C, Go M, Cheong YH, Park HS, Eom YB, Park SA.
      Anticancer Res. 2024 Oct;44(10):4283-4299. PMID: 39348965.
    • MicroRNA-34a-5p: A pivotal therapeutic target in gallbladder cancer.
      Oda T, Tsutsumi K, Obata T, Ueta E, Kikuchi T, Ako S, Fujii Y, Yamazaki T, Uchida D, Matsumoto K, Horiguchi S, Kato H, Okada H, Chijimatsu R, Otsuka M.
      Mol Ther Oncol. 2024 Feb 8;32(1):200765. PMID: 38596294.
    • SRSF6 modulates histone-chaperone HIRA splicing to orchestrate AR and E2F activity in prostate cancer.
      Montero-Hidalgo AJ, Jiménez-Vacas JM, Gómez-Gómez E, Porcel-Pastrana F, Sáez-Martínez P, Pérez-Gómez JM, Fuentes-Fayos AC, Blázquez-Encinas R, Sánchez-Sánchez R, González-Serrano T, Castro E, López-Soto PJ, Carrasco-Valiente J, Sarmento-Cabral A, Martinez-Fuentes AJ, Eyras E, Castaño JP, Sharp A, Olmos D, Gahete MD, Luque RM.
      Sci Adv. 2024 Oct 4;10(40):eado8231. PMID: 39356765.
    • Dysregulation of RNA-Exosome machinery is directly linked to major cancer hallmarks in prostate cancer: Oncogenic role of PABPN1.
      Sáez-Martínez P, Porcel-Pastrana F, Montero-Hidalgo AJ, Lozano de la Haba S, Sanchez-Sanchez R, González-Serrano T, Gómez-Gómez E, Martínez-Fuentes AJ, Jiménez-Vacas JM, Gahete MD, Luque RM.
      Cancer Lett. 2024 Mar 1;584:216604. PMID: 38244911.
    • Altered CELF4 splicing factor enhances pancreatic neuroendocrine tumors aggressiveness influencing mTOR and everolimus response.
      Alors-Pérez E, Pedraza-Arevalo S, Blázquez-Encinas R, García-Vioque V, Agraz-Doblas A, Yubero-Serrano EM, Sánchez-Frías ME, Serrano-Blanch R, Gálvez-Moreno MÁ, Gracia-Navarro F, Gahete MD, Arjona-Sánchez Á, Luque RM, Ibáñez-Costa A, Castaño JP.
      Mol Ther Nucleic Acids. 2023 Dec 5;35(1):102090. PMID: 38187140.
    • Polycomb group protein BMI1 protects neuroblastoma cells against DNA damage-induced apoptotic cell death.
      Akita N, Okada R, Mukae K, Sugino RP, Takenobu H, Chikaraishi K, Ochiai H, Yamaguchi Y, Ohira M, Koseki H, Kamijo T.
      Exp Cell Res. 2023 Jan 1;422(1):113412. PMID: 36370852.
    • E3 ubiquitin ligase TRIM21 targets TIF1γ to regulate β-catenin signaling in glioblastoma. Li Y, Bao L, Zheng H, Geng M, Chen T, Dai X, Xiao H, Yang L, Mao C, Qiu Y, Xu Y, Wang D, Li MX, Chen Q.
      Theranostics. 2023 Sep 4;13(14):4919-4935. PMID: 37771771.
    • PRPF8 increases the aggressiveness of hepatocellular carcinoma by regulating FAK/AKT pathway via fibronectin 1 splicing.
      López-Cánovas JL, Hermán-Sánchez N, Del Rio-Moreno M, Fuentes-Fayos AC, Lara-López A, Sánchez-Frias ME, Amado V, Ciria R, Briceño J, de la Mata M, Castaño JP, Rodriguez-Perálvarez M, Luque RM, Gahete MD.
      Exp Mol Med. 2023 Jan;55(1):132-142. PMID: 36609600.
    • Oncolytic Hairpin DNA Pair: Selective Cytotoxic Inducer through MicroRNA-Triggered DNA Self-Assembly.
      Morihiro K, Osumi H, Morita S, Hattori T, Baba M, Harada N, Ohashi R, Okamoto A.
      J Am Chem Soc. 2023 Jan 11;145(1):135-142. PMID: 36538570.
    • MicroRNA-1289 Functions as a Novel Tumor Suppressor in Oral Squamous Cell Carcinoma.
      Nakashiro K-i, Tokuzen N, Saika M, Shirai H, Kuribayashi N, Goda H, Uchida D.
      Cancers. 2023; 15(16):4138. https://doi.org/10.3390/cancers15164138
    • Plasma miR-1254 as a predictive biomarker of chemosensitivity and a target of nucleic acid therapy in esophageal cancer.
      Takashima Y, Komatsu S, Ohashi T, Kiuchi J, Nishibeppu K, Kamiya H, Arakawa H, Ishida R, Shimizu H, Arita T, Konishi H, Shiozaki A, Kubota T, Fujiwara H, Otsuji E.
      Cancer Sci. 2023 Jul;114(7):3027-3040. PMID: 37190912.
    • Spliceosomal profiling identifies EIF4A3 as a novel oncogene in hepatocellular carcinoma acting through the modulation of FGFR4 splicing.
      López-Cánovas JL, Hermán-Sánchez N, Moreno-Montilla MT, Del Rio-Moreno M, Alors-Perez E, Sánchez-Frias ME, Amado V, Ciria R, Briceño J, de la Mata M, Castaño JP, Rodriguez-Perálvarez M, Luque RM, Gahete MD.
      Clin Transl Med. 2022 Nov;12(11):e1102. PMID: 36419260.
    • Comprehensive genomics in androgen receptor-dependent castration-resistant prostate cancer identifies an adaptation pathway mediated by opioid receptor kappa 1.
      Makino Y, Kamiyama Y, Brown JB, Tanaka T, Murakami R, Teramoto Y, Goto T, Akamatsu S, Terada N, Inoue T, Kodama T, Ogawa O, Kobayashi T.
      Commun Biol. 2022 Apr 1;5(1):299. PMID: 35365763.
    • miRNA‑218 targets multiple oncogenes and is a therapeutic target for osteosarcoma.
      Sato K, Osaka E, Fujiwara K, Fujii R, Takayama T, Tokuhashi Y, Nakanishi K.
      Oncol Rep. 2022 May;47(5):92. PMID: 35293593.
    • Overexpression of Tetraspanin31 contributes to malignant potential and poor outcomes in gastric cancer.
      Takashima Y, Komatsu S, Ohashi T, Kiuchi J, Kamiya H, Shimizu H, Arita T, Konishi H, Shiozaki A, Kubota T, Okamoto K, Fujiwara H, Tsuda H, Otsuji E.
      Cancer Sci. 2022 Jun;113(6):1984-1998. PMID: 35307915.
    • miR-766-5p Targets Super-Enhancers by Downregulating CBP and BRD4.
      Gen Y, Muramatsu T, Inoue J, Inazawa J.
      Cancer Res. 2021 Oct 15;81(20):5190-5201. PMID: 34353856.
    • Cancer type‑SLCO1B3 promotes epithelial‑mesenchymal transition resulting in the tumour progression of non‑small cell lung cancer.
      Hase H, Aoki M, Matsumoto K, Nakai S, Nagata T, Takeda A, Ueda K, Minami K, Kitae K, Jingushi K, Ueda Y, Yamamoto M, Furukawa T, Sato M, Tsujikawa K.
      Oncol Rep. 2021 Jan;45(1):309-316. PMID: 33155667.
    • LncRNA OTUD6B-AS1 Induces Cisplatin Resistance in Cervical Cancer Cells Through Up-Regulating Cyclin D2 via miR-206.
      Hou H, Yu R, Zhao H, Yang H, Hu Y, Hu Y, Guo J.
      Front Oncol. 2021 Oct 22;11:777220. PMID: 34746018.
    • Depletion of tumor suppressor miRNA-148a in plasma relates to tumor progression and poor outcomes in gastric cancer.
      Komatsu S, Imamura T, Kiuchi J, Takashima Y, Kamiya H, Ohashi T, Konishi H, Shiozaki A, Kubota T, Okamoto K, Otsuji E.
      Am J Cancer Res. 2021 Dec 15;11(12):6133-6146. PMID: 35018247
    • De novo deoxyribonucleotide biosynthesis regulates cell growth and tumor progression in small-cell lung carcinoma.
      Maruyama A, Sato Y, Nakayama J, Murai J, Ishikawa T, Soga T, Makinoshima H.
      Sci Rep. 2021 Jun 29;11(1):13474. PMID: 34188151.
    • Pharmacological Inhibition of miR-130 Family Suppresses Bladder Tumor Growth by Targeting Various Oncogenic Pathways via PTPN1.
      Monoe Y, Jingushi K, Kawase A, Hirono T, Hirose R, Nakatsuji Y, Kitae K, Ueda Y, Hase H, Abe Y, Adachi J, Tomonaga T, Tsujikawa K.
      Int J Mol Sci. 2021 Apr 29;22(9):4751. PMID: 33947152
    • MicroRNA-206 suppresses mesothelioma progression via the Ras signaling axis.
      Singh A, Pruett N, Pahwa R, Mahajan AP, Schrump DS, Hoang CD.
      Mol Ther Nucleic Acids. 2021 Apr 3;24:669-681. PMID: 33996251
    • Theranostic application of miR-429 in HER2+ breast cancer.
      Cava C, Novello C, Martelli C, Lodico A, Ottobrini L, Piccotti F, Truffi M, Corsi F, Bertoli G, Castiglioni I.
      Theranostics. 2020 Jan 1;10(1):50-61. PMID: 31903105
    • Inhibition of Importin β1 Augments the Anticancer Effect of Agonistic Anti-Death Receptor 5 Antibody in TRAIL-resistant Tumor Cells.
      Kojima Y, Nishina T, Nakano H, Okumura K, Takeda K.
      Mol Cancer Ther. 2020 May;19(5):1123-1133. PMID: 32156787.
    • A novel long noncoding RNA Linc-ASEN represses cellular senescence through multileveled reduction of p21 expression.
      Lee HC, Kang D, Han N, Lee Y, Hwang HJ, Lee SB, You JS, Min BS, Park HJ, Ko YG, Gorospe M, Lee JS.
      Cell Death Differ. 2020 Jun;27(6):1844-1861. PMID: 31819156
    • Splicing machinery dysregulation drives glioblastoma development/aggressiveness: oncogenic role of SRSF3.
      Fuentes-Fayos AC, Vázquez-Borrego MC, Jiménez-Vacas JM, Bejarano L, Pedraza-Arévalo S, L-López F, Blanco-Acevedo C, Sánchez-Sánchez R, Reyes O, Ventura S, Solivera J, Breunig JJ, Blasco MA, Gahete MD, Castaño JP, Luque RM.
      Brain. 2020 Dec 5;143(11):3273-3293. PMID: 33141183.
    • miR-497-5p mediates starvation-induced death in colon cancer cells by targeting acyl-CoA synthetase-5 and modulation of lipid metabolism.
      Gharib E, Nasri Nasrabadi P, Reza Zali M.
      J Cell Physiol. 2020 Jul;235(7-8):5570-5589. PMID: 32012265.
      HT-29細胞およびSW480細胞（大腸がん細胞）の皮下腫瘍モデルマウスへのsiRNA局所投与。
    • miR-1293, a Candidate for miRNA-Based Cancer Therapeutics, Simultaneously Targets BRD4 and the DNA Repair Pathway.
      Takagawa Y, Gen Y, Muramatsu T, Tanimoto K, Inoue J, Harada H, Inazawa J.
      Mol Ther. 2020 Jun 3;28(6):1494-1505. PMID: 32320642.
    • MiR-1 Suppresses Proliferation of Osteosarcoma Cells by Up-regulating p21 via PAX3.
      Fujii R, Osaka E, Sato K, Tokuhashi Y.
      Cancer Genomics Proteomics. 2019 Jan-Feb;16(1):71-79. PMID: 30587501
    • TWEAK/Fn14 Interaction Confers Aggressive Properties to Cutaneous Squamous Cell Carcinoma.
      Hu G, Liang L, Liu Y, Liu J, Tan X, Xu M, Peng L, Zhai S, Li Q, Chu Z, Zeng W, Xia Y.
      J Invest Dermatol. 2019 Apr;139(4):796-806. PMID: 30414907
    • Augmented antitumor activity of 5-fluorouracil by double knockdown of MDM4 and MDM2 in colon and gastric cancer cells.
      Imanishi M, Yamamoto Y, Wang X, Sugaya A, Hirose M, Endo S, Natori Y, Yamato K, Hyodo I.
      Cancer Sci. 2019 Feb;110(2):639-649. PMID: 30488540.
    • Integrin α6β4-Src-AKT signaling induces cellular senescence by counteracting apoptosis in irradiated tumor cells and tissues.
      Jung SH, Lee M, Park HA, Lee HC, Kang D, Hwang HJ, Park C, Yu DM, Jung YR, Hong MN, Kim YN, Park HJ, Ko YG, Lee JS.
      Cell Death Differ. 2019 Jan;26(2):245-259. PMID: 29786073
    • Low levels of tumour suppressor miR-655 in plasma contribute to lymphatic progression and poor outcomes in oesophageal squamous cell carcinoma.
      Kiuchi J, Komatsu S, Imamura T, Nishibeppu K, Shoda K, Arita T, Kosuga T, Konishi H, Shiozaki A, Okamoto K, Fujiwara H, Ichikawa D, Otsuji E.
      Mol Cancer. 2019 Jan 4;18(1):2. PMID: 30609933
    • Absence of Cytosolic 2-Cys Prx Subtypes I and II Exacerbates TNF-α-Induced Apoptosis via Different Routes.
      Lee S, Lee JY, Lee EW, Park S, Kang DH, Min C, Lee DJ, Kang D, Song J, Kwon J, Kang SW.
      Cell Rep. 2019 Feb 19;26(8):2194-2211.e6. PMID: 30784599
    • The long noncoding RNA HORAS5 mediates castration-resistant prostate cancer survival by activating the androgen receptor transcriptional program.
      Parolia A, Venalainen E, Xue H, Mather R, Lin D, Wu R, Pucci P, Rogalski J, Evans JR, Feng F, Collins CC, Wang Y, Crea F.
      Mol Oncol. 2019 May;13(5):1121-1136. PMID: 30776192
    • Cadherin 11 Inhibition Downregulates β-catenin, Deactivates the Canonical WNT Signalling Pathway and Suppresses the Cancer Stem Cell-Like Phenotype of Triple Negative Breast Cancer.
      Satriyo PB, Bamodu OA, Chen JH, Aryandono T, Haryana SM, Yeh CT Chao TY.
      J Clin Med. 2019 Jan 27;8(2). pii: E148. PMID: 30691241
    • MicroRNA-215-5p Treatment Suppresses Mesothelioma Progression via the MDM2-p53-Signaling Axis.
      Singh A, Bhattacharyya N, Srivastava A, Pruett N, Ripley RT, Schrump DS, Hoang CD.
      Mol Ther. 2019 Sep 4;27(9):1665-1680. PMID: 31227395
    • MCL1 inhibition enhances the therapeutic effect of MEK inhibitors in KRAS-mutant lung adenocarcinoma cells.
      Tada M, Sumi T, Tanaka Y, Hirai S, Yamaguchi M, Miyajima M, Niki T, Takahashi H, Watanabe A, Sakuma Y.
      Lung Cancer. 2019 Jul;133:88-95. PMID: 31200834.
    • MicroRNA-8073: Tumor suppressor and potential therapeutic treatment.
      Mizoguchi A, Takayama A, Arai T, Kawauchi J, Sudo H.
      PLoS One. 2018 Dec 27;13(12):e0209750. PMID: 30589909 .
    • Screening for long noncoding RNAs associated with oral squamous cell carcinoma reveals the potentially oncogenic actions of DLEU1.
      Nishiyama K, Maruyama R, Niinuma T, Kai M, Kitajima H, Toyota M, Hatanaka Y, Igarashi T, Kobayashi JI, Ogi K, Dehari H, Miyazaki A, Yorozu A, Yamamoto E, Idogawa M4, Sasaki Y, Sugai T, Tokino T, Hiratsuka H, Suzuki H.
      Cell Death Dis. 2018 Aug 1;9(8):826. PMID: 30069008
    • Survivin knockdown induces senescence in TTF‑1-expressing, KRAS-mutant lung adenocarcinomas.
      Sumi T, Hirai S, Yamaguchi M, Tanaka Y, Tada M, Yamada G, Hasegawa T, Miyagi Y, Niki T, Watanabe A, Takahashi H, Sakuma Y.
      Int J Oncol. 2018 Apr 11. [Epub ahead of print] PMID: 29658609
    • miR-3140 suppresses tumor cell growth by targeting BRD4 via its coding sequence and downregulates the BRD4-NUT fusion oncoprotein.
      Tonouchi E, Gen Y, Muramatsu T, Hiramoto H, Tanimoto K, Inoue J, Inazawa J.
      Sci Rep. 2018 Mar 14;8(1):4482. PMID: 29540837
    • Depleted tumor suppressor miR-107 in plasma relates to tumor progression and is a novel therapeutic target in pancreatic cancer
      Taisuke Imamura, Shuhei Komatsu, Daisuke Ichikawa, Mahito Miyamae, Wataru Okajima, Takuma Ohashi, Jun Kiuchi, Keiji Nishibeppu, Hirotaka Konishi, Atsushi Shiozaki, Ryo Morimura, Hisashi Ikoma, Toshiya Ochiai, Kazuma Okamoto, Hiroki Taniguchi, Eigo Otsuji
      Sci Rep. 2017 Jul 18;7(1):5708. PMID: 28720759
    • Opposite effects of tumor protein D (TPD) 52 and TPD54 on oral squamous cell carcinoma cells.
      Kato K, Mukudai Y, Motohashi H, Ito C, Kamoshida S, Shimane T, Kondo S, Shirota T.
      Int J Oncol. 2017 May;50(5):1634-1646. PMID: 28339026
    • Ephrin-B2 reverse signaling regulates progression and lymph node metastasis of oral squamous cell carcinoma.
      Sasabe E, Tomomura A, Tomita R, Sento S, Kitamura N, Yamamoto T.
      PLoS One. 2017 Nov 30;12(11):e0188965. PMID: 29190834
    • Radiation-inducible miR-770-5p sensitizes tumors to radiation through direct targeting of PDZ-binding kinase.
      Lee HC, Her NG, Kang D, Jung SH, Shin J, Lee M, Bae IH, Kim YN, Park HJ, Ko YG, Lee JS
      Cell Death Dis. 2017 Mar 23;8(3):e2693. PMID: 28333152
    • The microRNA miR-516a-3p regulates the Wnt pathway by targeting extracellular sulfatase 1
      in human scirrhous gastric cancers: Anti-metastatic therapy via miRNA-based medicine
      Yoshifumi Takei, Akiko Suzuki, Keichiro Mihara, Kazuyoshi Yanagihara
      Medical Research Archives, Vol. 5, Issue 7, July 2017
    • ANKRD22 promotes progression of non-small cell lung cancer through transcriptional up-regulation of E2F1.
      Yin J, Fu W, Dai L, Jiang Z, Liao H, Chen W, Pan L, Zhao J.
      Sci Rep. 2017 Jun 30;7(1):4430. PMID: 28667340
    • Oncogenic role of rab escort protein 1 through EGFR and STAT3 pathway.
      Yun UJ, Sung JY, Park SY, Ye SK, Shim J, Lee JS, Hibi M, Bae YK, Kim YN.
      Cell Death Dis. 2017 Feb 23;8(2):e2621. PMID: 28230863
    • Pharmacological regulation of bladder cancer by miR-130 family seed-targeting LNA.
      Egawa H, Jingushi K, Hirono T, Hirose R, Nakatsuji Y, et al.
      (2016) Integr Mol Med. Volume 3(1): 457-463.
    • Nek2 siRNA therapy using a portal venous port-catheter system for liver metastasis in pancreatic cancer.
      Kokuryo T, Hibino S, Suzuki K, Watanabe K, Yokoyama Y, Nagino M, Senga T, Hamaguchi M.
      Cancer Sci. 2016 Sep;107(9):1315-20. PMID: 27316377
    • A therapeutic trial of human melanomas with combined small interfering RNAs targeting adaptor molecules p130Cas and paxillin activated under expression of ganglioside GD3.
      Makino Y, Hamamura K, Takei Y, Bhuiyan RH, Ohkawa Y, Ohmi Y, Nakashima H, Furukawa K, Furukawa K.
      Biochim Biophys Acta. 2016 Aug;1860(8):1753-63. PMID: 27068854
    • Docetaxel induced-JNK2/PHD1 signaling pathway increases degradation of HIF-1α and causes cancer cell death under hypoxia.
      Oh ET, Kim CW, Kim SJ, Lee JS, Hong SS, Park HJ.
      Sci Rep. 2016 Jun 6;6:27382. PMID: 27263528
    • Unfavorable neuroblastoma prognostic factor NLRR2 inhibits cell differentiation by transcriptional induction through JNK pathway.
      Sheikh A, Takatori A, Hossain MS, Hasan MK, Tagawa M, Nagase H, Nakagawara A.
      Cancer Sci. 2016 Sep;107(9):1223-32. PMID: 27357360
    • Regulation of SLD5 gene expression by miR-370 during acute growth of cancer cells.
      Yamane K, Naito H, Wakabayashi T, Yoshida H, Muramatsu F, Iba T, Kidoya H, Takakura N.
      Sci Rep. 2016 Aug 8;6:30941. PMID: 27499248
    • Usefulness of microRNA‑375 as a prognostic and therapeutic tool in esophageal squamous cell carcinoma.
      Isozaki, Y., Hoshino, I., Akutsu, Y., Hanari, N., Mori, M., Nishimori, T., Murakami, K., Akanuma, N., Takeshita, N., Maruyama, T., Toyozumi, T., Takahashi, M., Suito, H., & Matsubara, H.
      Int J Oncol. 2015 Mar;46(3):1059-66. PMID: 25501018
    • Arl4c expression in colorectal and lung cancers promotes tumorigenesis and may represent a novel therapeutic target.
      Fujii S, Matsumoto S, Nojima S, Morii E, Kikuchi A.
      Oncogene. 2015 Sep 10;34(37):4834-44. PMID: 25486429
    • MiR-634 activates the mitochondrial apoptosis pathway and enhances chemotherapy-induced cytotoxicity.
      Fujiwara N, Inoue J, Kawano T, Tanimoto K, Kozaki KI, Inazawa J.
      Cancer Res. 2015 Sep 15;75(18):3890-901. PMID: 26216549
    • RFPL4A increases the G1 population and decreases sensitivity to chemotherapy in human colorectal cancer cells.
      Naito A, Yamamoto H, Kagawa Y, Naito Y, Okuzaki D, Otani K, Iwamoto Y, Maeda S, Kikuta J, Nishikawa K, Uemura M, Nishimura J, Hata T, Takemasa I, Mizushima T, Ishii H, Doki Y, Mori M, Ishii M.
      J Biol Chem. 2015 Mar 6;290(10):6326-37. PMID: 25605732
    • Efficient inhibition of tumor angiogenesis and growth by a synthetic peptide blocking S100A4-methionine aminopeptidase 2 interaction.
      Ochiya T, Takenaga K, Asagiri M, Nakano K, Satoh H, Watanabe T,
      Imajoh-Ohmi S, Endo H.
      Mol Ther Methods Clin Dev. 2015 Apr 1;2:15008. PMID: 26029719
    • Ubiquilin 2 enhances osteosarcoma progression through resistance to hypoxic stress.
      Tsukamoto S, Shimada K, Honoki K, Kido A, Akahane M, Tanaka Y, Konishi N.
      Oncol Rep. 2015 Apr;33(4):1799-806. PMID: 25672654
    • APOBEC3B-Mediated Cytidine Deamination Is Required for Estrogen Receptor Action in Breast Cancer.
      Periyasamy M, Patel H, Lai CF, Nguyen VT, Nevedomskaya E, Harrod A, Russell R, Remenyi J, Ochocka AM, Thomas RS, Fuller-Pace F, Győrffy B, Caldas C, Navaratnam N, Carroll JS, Zwart W, Coombes RC, Magnani L, Buluwela L, Ali S.
      Cell Rep. 2015 Oct 6;13(1):108-21. PMID: 26411678
    • Aurora kinase A has a significant role as a therapeutic target and clinical biomarker in endometrial cancer.
      Umene K, Yanokura M, Banno K, Irie H, Adachi M, Iida M, Nakamura K, Nogami Y, Masuda K, Kobayashi Y, Tominaga E, Aoki D.
      Int J Oncol. 2015 Apr;46(4):1498-506. PMID: 25625960
    • Glyoxalase I is differentially expressed in cutaneous neoplasms and contributes to the progression of squamous cell carcinoma.
      Zou XY, Ding D, Zhan N, Liu XM, Pan C, Xia YM.
      J Invest Dermatol. 2015 Feb;135(2):589-98. PMID: 25184957
    • RNA interference against cancer/testis genes identifies DUSP21 as a potential therapeutic target in human hepatocellular carcinoma.
      Deng Q, Li KY, Chen H, Dai JH, Zhai YY, Wang Q, Li N, Wang YP, Han ZG.
      Hepatology. 2014 Feb;59(2):518-30. PMID: 23929653
    • MicroRNAs cooperatively inhibit a network of tumor suppressor genes to promote pancreatic tumor growth and progression.
      Frampton AE, Castellano L, Colombo T, Giovannetti E, Krell J, Jacob J, Pellegrino L, Roca-Alonso L, Funel N, Gall TM, De Giorgio A, Pinho FG, Fulci V, Britton DJ, Ahmad R, Habib NA, Coombes RC, Harding V, Knösel T, Stebbing J, Jiao LR.
      Gastroenterology. 2014 Jan;146(1):268-77.e18. PMID: 24120476
    • Guanine nucleotide-binding protein 1 is one of the key molecules contributing to cancer cell radioresistance.
      Fukumoto M, Amanuma T, Kuwahara Y, Shimura T, Suzuki M, Mori S, Kumamoto H, Saito Y, Ohkubo Y, Duan Z, Sano K, Oguchi T, Kainuma K, Usami S, Kinoshita K, Lee I, Fukumoto M.
      Cancer Sci. 2014 Oct;105(10):1351-9. PMID: 25098609
    • Paired box 2 upregulates androgen receptor gene expression in androgen-independent prostate cancer.
      Ito S, Ueda T, Ueno A, Nakagawa H, Taniguchi H, Hongo F, Kamoi K, Okihara K, Kawauchi A, Miki T.
      FEBS J. 2014 Oct;281(19):4506-18. PMID: 25132193
    • High expression of protein tyrosine kinase 7 significantly associates with invasiveness and poor prognosis in intrahepatic cholangiocarcinoma.
      Jin J, Ryu HS, Lee KB, Jang JJ.
      PLoS One. 2014 Feb 28;9(2):e90247. PMID: 24587299
    • Significant involvement of herpesvirus entry mediator in human esophageal squamous cell carcinoma.
      Migita K, Sho M, Shimada K, Yasuda S, Yamato I, Takayama T, Matsumoto S, Wakatsuki K, Hotta K, Tanaka T, Ito M, Konishi N, Nakajima Y.
      Cancer. 2014 Mar 15;120(6):808-17. PMID: 24249528
    • Targeting CB2-GPR55 Receptor Heteromers Modulates Cancer Cell Signaling.
      Moreno E, Andradas C, Medrano M, Caffarel MM, Pérez-Gómez E, Blasco-Benito S, Gómez-Cañas M, Pazos MR, Irving AJ, Lluís C, Canela EI, Fernández-Ruiz J, Guzmán M, McCormick PJ, Sánchez C.
      J Biol Chem. 2014 Aug 8;289(32):21960-72. PMID: 24942731
    • miR-296/Scribble axis is deregulated in human breast cancer and miR-296 restoration reduces tumour growth in vivo.
      Savi F, Forno I, Faversani A, Luciani A, Caldiera S, Gatti S, Foa P, Ricca D, Bulfamante G, Vaira V, Bosari S.
      Clin Sci (Lond). 2014 Aug;127(4):233-42. PMID: 24527800
    • AFAP1L1, a novel associating partner with vinculin, modulates cellular morphology and motility, and promotes the progression of colorectal cancers.
      Takahashi R, Nagayama S, Furu M, Kajita Y, Jin Y, Kato T, Imoto S, Sakai Y, Toguchida J.
      Cancer Med. 2014 Aug;3(4):759-74. PMID: 24723436
    • Chondroitin sulphate N-acetylgalactosaminyl-transferase-1 inhibits recovery from neural injury.
      Takeuchi K, Yoshioka N, Higa Onaga S, Watanabe Y, Miyata S, Wada Y, Kudo C, Okada M, Ohko K, Oda K, Sato T, Yokoyama M, Matsushita N, Nakamura M, Okano H, Sakimura K, Kawano H, Kitagawa H, Igarashi M.
      Nat Commun. 2013;4:2740. PMID: 24220492
    • Potential of tumor-suppressive miR-596 targeting LGALS3BP as a therapeutic agent in oral cancer.
      Endo H, Muramatsu T, Furuta M, Uzawa N, Pimkhaokham A, Amagasa T, Inazawa J, Kozaki K.
      Carcinogenesis. 2013 Mar;34(3):560-9. PMID: 23233740
    • Y-box binding protein-1 regulates cell proliferation and is associated with clinical outcomes of osteosarcoma.
      Fujiwara-Okada Y, Matsumoto Y, Fukushi J, Setsu N, Matsuura S, Kamura S, Fujiwara T, Iida K, Hatano M, Nabeshima A, Yamada H, Ono M, Oda Y, Iwamoto Y.
      Br J Cancer. 2013 Mar 5;108(4):836-47. PMID: 23462806
    • miR-146a enhances the oncogenicity of oral carcinoma by concomitant targeting of the IRAK1, TRAF6 and NUMB genes.
      Hung PS, Liu CJ, Chou CS, Kao SY, Yang CC, Chang KW, Chiu TH, Lin SC.
      PLoS One. 2013 Nov 26;8(11):e79926. PMID: 24302991
      KAI?
    • Ubiquitin C-terminal Hydrolase L1 (UCH-L1) Acts as a Novel Potentiator of Cyclin-dependent Kinases to Enhance Cell Proliferation, Independent of its Hydrolase Activity.
      Kabuta T, Mitsui T, Takahashi M, Fujiwara Y, Kabuta C, Konya C, Tsuchiya Y, Hatanaka Y, Uchida K, Hohjoh H, Wada K.
      J Biol Chem. 2013 May 3;288(18):12615-26. PMID: 23543736
    • Cell cycle-dependent Rho GTPase activity dynamically regulates cancer cell motility and invasion in vivo.
      Kagawa Y, Matsumoto S, Kamioka Y, Mimori K, Naito Y, Ishii T, Okuzaki D, Nishida N, Maeda S, Naito A, Kikuta J, Nishikawa K, Nishimura J, Haraguchi N, Takemasa I, Mizushima T, Ikeda M, Yamamoto H, Sekimoto M, Ishii H, Doki Y, Matsuda M, Kikuchi A, Mori M, Ishii M.
      PLoS One. 2013 Dec 30;8(12):e83629. PMID: 24386239
    • In vivo delivery of siRNA targeting vasohibin-2 decreases tumor angiogenesis and suppresses tumor growth in ovarian cancer.
      Koyanagi T, Suzuki Y, Saga Y, Machida S, Takei Y, Fujiwara H, Suzuki M, Sato Y.
      Cancer Sci. 2013 Dec;104(12):1705-10. PMID: 24118388
    • Targeting the Vav3 oncogene enhances docetaxel-induced apoptosis through the inhibition of androgen receptor phosphorylation in LNCaP prostate cancer cells under chronic hypoxia.
      Nomura T, Yamasaki M, Hirai K, Inoue T, Sato R, Matsuura K, Moriyama M, Sato F, Mimata H.
      Mol Cancer. 2013 Apr 8;12:27. PMID: 23566222
    • MicroRNA-196a is a putative diagnostic biomarker and therapeutic target for laryngeal cancer.
      Saito K, Inagaki K, Kamimoto T, Ito Y, Sugita T, Nakajo S, Hirasawa A, Iwamaru A, Ishikura T, Hanaoka H, Okubo K, Onozaki T, Zama T.
      PLoS One. 2013 Aug 14;8(8):e71480. PMID: 23967217
    • YB-1 suppression induces STAT3 proteolysis and sensitizes renal cancer to interferon-α.
      Takeuchi A, Shiota M, Tatsugami K, Yokomizo A, Kuroiwa K, Dejima T, Tanaka S, Itsumi M, Eto M, Naito S.
      Cancer Immunol Immunother. 2013 Mar;62(3):517-27. PMID: 23052245
    • Temozolomide suppresses MYC via activation of TAp63 to inhibit progression of human glioblastoma.
      Yamaki T, Suenaga Y, Iuchi T, Alagu J, Takatori A, Itami M, Araki A, Ohira M, Inoue M, Kageyama H, Yokoi S, Saeki N, Nakagawara A.
      Sci Rep. 2013;3:1160. PMID: 23362460
    • Plasma membrane-associated sialidase (NEU3) regulates progression of prostate cancer to androgen-independent growth through modulation of androgen receptor signaling.
      Kawamura S, Sato I, Wada T, Yamaguchi K, Li Y, Li D, Zhao X, Ueno S, Aoki H, Tochigi T, Kuwahara M, Kitamura T, Takahashi K, Moriya S, Miyagi T.
      Cell Death Differ. 2012 Jan;19(1):170-9. PMID:21681193
    • Wig1 prevents cellular senescence by regulating p21 mRNA decay through control of RISC recruitment.
      Kim BC, Lee HC, Lee JJ, Choi CM, Kim DK, Lee JC, Ko YG, Lee JS.
      EMBO J. 2012 Nov 14;31(22):4289-303. PMID: 23085987
    • Anti-tumor effect of AlkB homolog 3 knockdown in hormone-independent prostate cancer cells.
      Koike K, Ueda Y, Hase H, Kitae K, Fusamae Y, Masai S, Inagaki T, Saigo Y, Hirasawa S, Nakajima K, Ohshio I, Makino Y, Konishi N, Yamamoto H, Tsujikawa K.
      Curr Cancer Drug Targets. 2012 Sep;12(7):847-56. PMID:22515525
    • Up-regulation of endogenous PML induced by a combination of interferon-beta and temozolomide enhances p73/YAP-mediated apoptosis in glioblastoma.
      Okazaki T, Kageji T, Kuwayama K, Kitazato KT, Mure H, Hara K, Morigaki R, Mizobuchi Y, Matsuzaki K, Nagahiro S.
      Cancer Lett. 2012 Oct 28;323(2):199-207. PMID:22542810
    • D-amino acid oxidase gene therapy sensitizes glioma cells to the antiglycolytic effect of 3-bromopyruvate.
      El Sayed SM, Abou El-Magd RM, Shishido Y, Chung SP, Sakai T, Watanabe H, Kagami S, Fukui K.
      Cancer Gene Ther. 2012 Jan;19(1):1-18. PMID:21921941
    • ALKBH3 contributes to survival and angiogenesis of human urothelial carcinoma cells through NADPH oxidase and Tweak/Fn14/VEGF signals.
      Shimada K, Fujii T, Anai S, Fujimoto K, Konishi N.
      Clin Cancer Res. 2012 Oct 1;18(19):5247-55. PMID:22850567
    • ZDHHC8 knockdown enhances radiosensitivity and suppresses tumor growth in a mesothelioma mouse model.
      Sudo H, Tsuji AB, Sugyo A, Ogawa Y, Sagara M, Saga T.
      Cancer Sci. 2012 Feb;103(2):203-9. PMID:22017350
    • Therapeutic Potential of SOX2 Inhibition for Embryonal Carcinoma.
      Ushida H, Chano T, Minami K, Kita H, Kawakami T, Okabe H, Okada Y, Okamoto K.
      J Urol. 2012 May;187(5):1876-81. PMID:22425046
    • NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma.
      Yamaguchi T, Yanagisawa K, Sugiyama R, Hosono Y, Shimada Y, Arima C, Kato S, Tomida S, Suzuki M, Osada H, Takahashi T.
      Cancer Cell. 2012 Mar 20;21(3):348-61. PMID:22439932
    • Nestin as a novel therapeutic target for pancreatic cancer via tumor angiogenesis.
      Yamahatsu K1, Matsuda Y, Ishiwata T, Uchida E, Naito Z.
      Int J Oncol. 2012 May;40(5):1345-57. PMID: 22246533
    • PCA-1/ALKBH3 contributes to pancreatic cancer by supporting apoptotic resistance and angiogenesis.
      Yamato I, Sho M, Shimada K, Hotta K, Ueda Y, Yasuda S, Shigi N, Konishi N, Tsujikawa K, Nakajima Y.
      Cancer Res. 2012 Sep 15;72(18):4829-39. PMID:22826605
    • The orphan G protein-coupled receptor GPR55 promotes cancer cell proliferation via ERK.
      Andradas C, Caffarel MM, Pérez-Gómez E, Salazar M, Lorente M, Velasco G, Guzmán M, Sánchez C.
      Oncogene. 2011 Jan 13;30(2):245-52. PMID:20818416 short communication
    • RECQL1 and WRN proteins are potential therapeutic targets in head and neck squamous cell carcinoma.
      Arai A, Chano T, Futami K, Furuichi Y, Ikebuchi K, Inui T, Tameno H, Ochi Y, Shimada T, Hisa Y, Okabe H.
      Cancer Res. 2011 Jul 1;71(13):4598-607. PMID:21571861
    • GEP100-Arf6-AMAP1-cortactin pathway frequently used in cancer invasion is activated by VEGFR2 to promote angiogenesis.
      Hashimoto A, Hashimoto S, Ando R, Noda K, Ogawa E, Kotani H, Hirose M, Menju T, Morishige M, Manabe T, Toda Y, Ishida S, Sabe H.
      PLoS One. 2011;6(8):e23359. PMID:21858086
    • Transient silencing of galectin-3 expression promotes both in vitro and in vivo drug-induced apoptosis of human pancreatic carcinoma cells.
      Kobayashi T, Shimura T, Yajima T, Kubo N, Araki K, Wada W, Tsutsumi S, Suzuki H, Kuwano H, Raz A.
      Clin Exp Metastasis. 2011 Apr;28(4):367-76. PMID:21331750
    • Stimulation of the midkine/ALK axis renders glioma cells resistant to cannabinoid antitumoral action.
      Lorente M, Torres S, Salazar M, Carracedo A, Hernández-Tiedra S, Rodríguez-Fornés F, García-Taboada E, Meléndez B, Mollejo M, Campos-Martín Y, Lakatosh SA, Barcia J, Guzmán M, Velasco G.
      Cell Death Cell Death Differ. 2011 Jun;18(6):959-73. PMID:21233844
    • miR-135b mediates NPM-ALK-driven oncogenicity and renders IL-17-producing immunophenotype to anaplastic large cell lymphoma.
      Matsuyama H, Suzuki HI, Nishimori H, Noguchi M, Yao T, Komatsu N, Mano H, Sugimoto K, Miyazono K.
      Blood. 2011 Dec 22;118(26):6881-92. PMID:22042699
    • ZNF689 suppresses apoptosis of hepatocellular carcinoma cells through the down-regulation of Bcl-2 family members.
      Shigematsu S, Fukuda S, Nakayama H, Inoue H, Hiasa Y, Onji M, Higashiyama S.
      Exp Cell Res. 2011 Aug 1;317(13):1851-9. PMID:21624362
    • The metastasis-associated microRNA miR-516a-3p is a novel therapeutic target for inhibiting peritoneal dissemination of human scirrhous gastric cancer.
      Takei Y, Takigahira M, Mihara K, Tarumi Y, Yanagihara K.
      Cancer Res. 2011 Feb 15;71(4):1442-1453. PMID:21169410
    • Synthetic siRNA targeting the breakpoint of EWS/Fli-1 inhibits growth of Ewing sarcoma xenografts in a mouse model.
      Takigami I, Ohno T, Kitade Y, Hara A, Nagano A, Kawai G, Saitou M, Matsuhashi A, Yamada K, Shimizu K.
      Int J Cancer. 2011 Jan 1;128(1):216-26. PMID:20648560
    • ALKBH3, a human AlkB homologue, contributes to cell survival in human non-small-cell lung cancer.
      Tasaki M, Shimada K, Kimura H, Tsujikawa K, Konishi N.
      Br J Cancer. 2011 Feb 15;104(4):700-6. PMID:21285982
    • Suppression of SOCS3 increases susceptibility of renal cell carcinoma to interferon-α.
      Tomita S, Ishibashi K, Hashimoto K, Sugino T, Yanagida T, Kushida N, Shishido K, Aikawa K, Sato Y, Suzutani T, Yamaguchi O.
      Cancer Sci. 2011 Jan;102(1):57-63. PMID:21054677
    • miR-152 is a tumor suppressor microRNA that is silenced by DNA hypermethylation in endometrial cancer.
      Tsuruta T, Kozaki K, Uesugi A, Furuta M, Hirasawa A, Imoto I, Susumu N, Aoki D, Inazawa J.
      Cancer Res. 2011 Oct 15;71(20):6450-62. PMID:21868754
    • Anti-tumoral action of cannabinoids on hepatocellular carcinoma: role of AMPK-dependent activation of autophagy.
      Vara D, Salazar M, Olea-Herrero N, Guzmán M, Velasco G, Díaz-Laviada I.
      Cell Death Differ. 2011 Jul;18(7):1099-111. PMID:21475304
    • The cancer/testis antigen prostate-associated gene 4 (PAGE4) is a highly intrinsically disordered protein.
      Zeng Y, He Y, Yang F, Mooney S, Getzenberg R, Orban J, Kulkarni P.　
      J Biol Chem. 2011 Apr 22;286(16):13985-94. PMID:21357425
    • Atelocollagen-delivered siRNA targeting the FABP5 gene as an experimental therapy for prostate cancer in mouse xenografts.
      Forootan SS, Bao ZZ, Forootan FS, Kamalian L, Zhang Y, Bee A, Foster CS, Ke Y.
      Int J Oncol. 2010 Jan;36(1):69-76. PMID:19956834
    • Shank-interacting protein-like 1 promotes tumorigenesis via PTEN inhibition in human tumor cells.
      He L, Ingram A, Rybak AP, Tang D.
      J Clin Invest. 2010 Jun 1;120(6):2094-108. PMID:20458142
    • miR-31 ablates expression of the HIF regulatory factor FIH to activate the HIF pathway in head and neck carcinoma.
      Liu CJ, Tsai MM, Hung PS, Kao SY, Liu TY, Wu KJ, Chiou SH, Lin SC, Chang KW.
      Cancer Res. 2010 Feb 15;70(4):1635-44. PMID:20145132
    • Cyclin K and cyclin D1b are oncogenic in myeloma cells.
      Marsaud V, Tchakarska G, Andrieux G, Liu JM, Dembele D, Jost B, Wdzieczak-Bakala J, Renoir JM, Sola B.
      Mol Cancer. 2010 May 10;9:103. PMID:20459741
    • EWS/Fli-1 chimeric fusion gene upregulates vascular endothelial growth factor-A.
      Nagano A, Ohno T, Shimizu K, Hara A, Yamamoto T, Kawai G, Saitou M, Takigami I, Matsuhashi A, Yamada K, Takei Y.
      Int J Cancer. 2010 Jun 15;126(12):2790-8. PMID:19642105
    • Combined functional genome survey of therapeutic targets for hepatocellular carcinoma.
      Satow R, Shitashige M, Kanai Y, Takeshita F, Ojima H, Jigami T, Honda K, Kosuge T, Ochiya T, Hirohashi S, Yamada T.
      Clin Cancer Res. 2010 May 1;16(9):2518-28. PMID:20388846
    • Role of syndecan-1 (CD138) in cell survival of human urothelial carcinoma.
      Shimada K, Nakamura M, De Velasco MA, Tanaka M, Ouji Y, Miyake M, Fujimoto K, Hirao K, Konishi N.
      Cancer Sci. 2010 Jan;101(1):155-60. PMID: 19860843
    • Traf2- and Nck-interacting kinase is essential for Wnt signaling and colorectal cancer growth.
      Shitashige M, Satow R, Jigami T, Aoki K, Honda K, Shibata T, Ono M, Hirohashi S, Yamada T.
      Cancer Res. 2010 Jun 15;70(12):5024-33. PMID:20530691
    • Knockdown of COPA, identified by loss-of-function screen, induces apoptosis and suppresses tumor growth in mesothelioma mouse model.
      Sudo H, Tsuji AB, Sugyo A, Kohda M, Sogawa C, Yoshida C, Harada YN, Hino O, Saga T.
      Genomics. 2010 Apr;95(4):210-6. PMID:20153416
    • Mutant mouse p53 transgene elevates the chemical induction of tumors that respond to gene silencing with siRNA.
      Tanooka H, Tatsumi K, Tsuji H, Noda Y, Katsube T, Ishii H, Ootsuyama A, Takeshita F, Ochiya T.
      Cancer Gene Ther. 2010 Jan;17(1):1-10. PMID:19557034
    • beta-catenin small interfering RNA successfully suppressed progression of multiple myeloma in a mouse model.
      Ashihara E, Kawata E, Nakagawa Y, Shimazaski C, Kuroda J, Taniguchi K, Uchiyama H, Tanaka R, Yokota A, Takeuchi M, Kamitsuji Y, Inaba T, Taniwaki M, Kimura S, Maekawa T.
      Clin Cancer Res. 2009 Apr 15;15(8):2731-8. PMID: 19351774
    • Amphiregulin is a factor for resistance of glioma cells to cannabinoid-induced apoptosis.
      Lorente M, Carracedo A, Torres S, Natali F, Egia A, Hernández-Tiedra S, Salazar M, Blázquez C, Guzmán M, Velasco G.
      Glia. 2009 Oct;57(13):1374-85. PMID:19229996
    • Promotion of glioma cell survival by acyl-CoA synthetase 5 under extracellular acidosis conditions.
      Mashima T, Sato S, Sugimoto Y, Tsuruo T, Seimiya H.
      Oncogene. 2009 Jan 8;28(1):9-19. PMID: 18806831
    • A novel human AlkB homologue, ALKBH8, contributes to human bladder cancer progression.
      Shimada K, Nakamura M, Anai S, De Velasco M, Tanaka M, Tsujikawa K, Ouji Y, Konishi N.
      Cancer Res. 2009 Apr 1;69(7):3157-64. PMID:19293182
    • Syndecan-1, a new target molecule involved in progression of androgen-independent prostate cancer.
      Shimada K, Nakamura M, De Velasco MA, Tanaka M, Ouji Y, Konishi N.
      Cancer Sci. 2009 Jul;100(7):1248-54. PMID:19432893
    • Functional genome screen for therapeutic targets of osteosarcoma.
      Yamaguchi U, Honda K, Satow R, Kobayashi E, Nakayama R, Ichikawa H, Shoji A, Shitashige M, Masuda M, Kawai A, Chuman H, Iwamoto Y, Hirohashi S, Yamada T.
      Cancer Sci. 2009 Dec;100(12):2268-74. PMID:19725836
    • Characterization of the recurrent 8p11-12 amplicon identifies PPAPDC1B, a phosphatase protein, as a new therapeutic target in breast cancer.
      Bernard-Pierrot I, Gruel N, Stransky N, Vincent-Salomon A, Reyal F, Raynal V, Vallot C, Pierron G, Radvanyi F, Delattre O.
      Cancer Res. 2008 Sep 1;68(17):7165-75. PMID:18757432
    • RPN2 gene confers docetaxel resistance in breast cancer.
      Honma K, Iwao-Koizumi K, Takeshita F, Yamamoto Y, Yoshida T, Nishio K, Nagahara S, Kato K, Ochiya T.
      Nat Med. 2008 Sep;14(9):939-48. PMID:18724378
    • A small interfering RNA targeting proteinase-activated receptor-2 is effective in suppression of tumor growth in a Panc1 xenograft model.
      Iwaki K, Shibata K, Ohta M, Endo Y, Uchida H, Tominaga M, Okunaga R, Kai S, Kitano S.
      Int J Cancer. 2008 Feb 1;122(3):658-63. PMID:17935125
    • ATP citrate lyase: activation and therapeutic implications in non-small cell lung cancer.
      Migita T, Narita T, Nomura K, Miyagi E, Inazuka F, Matsuura M, Ushijima M, Mashima T, Seimiya H, Satoh Y, Okumura S, Nakagawa K, Ishikawa Y.
      Cancer Res. 2008 Oct 15;68(20):8547-54. PMID:18922930
    • Effects of small interfering RNA targeting thymidylate synthase on survival of ACC3 cells from salivary adenoid cystic carcinoma.
      Shirasaki T, Maruya S, Mizukami H, Kakehata S, Kurotaki H, Yagihashi S, Shinkawa H.
      BMC Cancer. 2008 Nov 26;8:348. PMID:19036131
    • Heregulin-induced activation of ErbB3 by EGFR tyrosine kinase activity promotes tumor growth and metastasis in melanoma cells.
      Ueno Y, Sakurai H, Tsunoda S, Choo MK, Matsuo M, Koizumi K, Saiki I.
      Int J Cancer. 2008 Jul 15;123(2):340-7. PMID:18398842
    • New highly potent and specific E6 and E7 siRNAs for treatment of HPV16 positive cervical cancer.
      Yamato K, Yamada T, Kizaki M, Ui-Tei K, Natori Y, Fujino M, Nishihara T, Ikeda Y, Nasu Y, Saigo K, Yoshinouchi M.
      Cancer Gene Ther. 2008 Mar;15(3):140-53. PMID:18157144
    • Down regulation of BRCA2 causes radio-sensitization of human tumor cells in vitro and in vivo.
      Yu D, Sekine E, Fujimori A, Ochiya T, Okayasu R.
      Cancer Sci. 2008 Apr;99(4):810-5. PMID:18377429
    • Nek2 as an effective target for inhibition of tumorigenic growth and peritoneal dissemination of cholangiocarcinoma.
      Kokuryo T, Senga T, Yokoyama Y, Nagino M, Nimura Y, Hamaguchi M.
      Cancer Res. 2007 Oct 15;67(20):9637-42. PMID:17942892
    • Single-injection ornithine decarboxylase-directed antisense therapy using atelocollagen to suppress human cancer growth.
      Nakazawa K, Nemoto T, Hata T, Seyama Y, Nagahara S, Sano A, Itoh H, Nagai Y, Kubota S.
      Cancer. 2007 Mar 1;109(5):993-1002. PMID:17318877
    • Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells.
      Tazawa H, Tsuchiya N, Izumiya M, Nakagama H.
      Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15472-7. PMID:17875987
    • Involvement of aminopeptidase N in enhanced chemosensitivity to paclitaxel in ovarian carcinoma in vitro and in vivo.
      Yamashita M, Kajiyama H, Terauchi M, Shibata K, Ino K, Nawa A, Mizutani S, Kikkawa F.
      Int J Cancer. 2007 May 15;120(10):2243-50. PMID:17266036
    • Intratumor injection of small interfering RNA-targeting human papillomavirus 18 E6 and E7 successfully inhibits the growth of cervical cancer.
      Fujii T, Saito M, Iwasaki E, Ochiya T, Takei Y, Hayashi S, Ono A, Hirao N, Nakamura M, Kubushiro K, Tsukazaki K, Aoki D.
      Int J Oncol. 2006 Sep;29(3):541-8. PMID:16865269
    • Small interfering RNA targeting epidermal growth factor receptor enhances chemosensitivity to cisplatin, 5-fluorouracil and docetaxel in head and neck squamous cell carcinoma.
      Nozawa H, Tadakuma T, Ono T, Sato M, Hiroi S, Masumoto K, Sato Y.
      Cancer Sci. 2006 Oct;97(10):1115-24. PMID:16984384
    • Combinational antitumor effect of siRNA against midkine and paclitaxel on growth of human prostate cancer xenografts.
      Takei Y, Kadomatsu K, Goto T, Muramatsu T.
      Cancer. 2006 Aug 15;107(4):864-73. PMID:16832814
    • The human papillomavirus E6 and E7 inducible oncogene, hWAPL, exhibits potential as a therapeutic target.
      Kuroda M, Kiyono T, Oikawa K, Yoshida K, Mukai K.
      Br J Cancer. 2005 Jan 31;92(2):290-3. PMID:15655544
    • Morpholino antisense oligomer targeting human midkine: its application for cancer therapy.
      Takei Y, Kadomatsu K, Yuasa K, Sato W, Muramatsu T.
      Int J Cancer. 2005 Apr 10;114(3):490-7. PMID:15578698
    • Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo.
      Minakuchi Y, Takeshita F, Kosaka N, Sasaki H, Yamamoto Y, Kouno M, Honma K, Nagahara S, Hanai K, Sano A, Kato T, Terada M, Ochiya T.
      Nucleic Acids Res. 2004 Jul 22;32(13):e109. PMID:15272050
    • A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics.
      Takei Y, Kadomatsu K, Yuzawa Y, Matsuo S, Muramatsu T.
      Cancer Res. 2004 May 15;64(10):3365-70. PMID:15150085
    • Antisense oligodeoxynucleotide against HST-1/FGF-4 suppresses tumorigenicity of an orthotopic model for human germ cell tumor in nude mice.
      Hirai K, Sasaki H, Sakamoto H, Takeshita F, Asano K, Kubota Y, Ochiya T, Terada M.
      J Gene Med. 2003 Nov;5(11):951-7. PMID:14601132
    • 5'-,3'-inverted thymidine-modified antisense oligodeoxynucleotide targeting midkine. Its design and application for cancer therapy.
      Takei Y, Kadomatsu K, Itoh H, Sato W, Nakazawa K, Kubota S, Muramatsu T.
      J Biol Chem. 2002 Jun 28;277(26):23800-6. PMID: 11959856
    • Antisense oligodeoxynucleotide targeted to Midkine, a heparin-binding growth factor, suppresses tumorigenicity of mouse rectal carcinoma cells.
      Takei Y, Kadomatsu K, Matsuo S, Itoh H, Nakazawa K, Kubota S, Muramatsu T.
      Cancer Res. 2001 Dec 1;61(23):8486-91. PMID:11731432
    • Knockdown of mechanosensitive adaptor Hic-5 ameliorates post-traumatic osteoarthritis in rats through repression of MMP-13.
      Miyauchi A, Noguchi M, Lei XF, Sakaki M, Kobayashi-Tanabe M, Haraguchi S, Miyazaki A, Kim-Kaneyama JR.
      Sci Rep. 2023 May 8;13(1):7446. PMID: 37156857.
    • Carotenoid transporter CD36 expression depends on hypoxia-inducible factor-1α in mouse soleus muscles.
      Kitakaze T, Sugihira T, Kameyama H, Maruchi A, Kobayashi Y, Harada N, Yamaji R.
      J Clin Biochem Nutr. 2022 Sep;71(2):112-121. PMID: 36213788.
    • Both microRNA-455-5p and -3p repress hypoxia-inducible factor-2α expression and coordinately regulate cartilage homeostasis.
      Ito Y, Matsuzaki T, Ayabe F, Mokuda S, Kurimoto R, Matsushima T, Tabata Y, Inotsume M, Tsutsumi H, Liu L, Shinohara M, Tanaka Y, Nakamichi R, Nishida K, Lotz MK, Asahara H.
      Nat Commun. 2021 Jul 6;12(1):4148. PMID: 34230481.
    • MiR-199-3p enhances muscle regeneration and ameliorates aged muscle and muscular dystrophy.
      Fukuoka M, Fujita H, Numao K, Nakamura Y, Shimizu H, Sekiguchi M, Hohjoh H.
      Commun Biol. 2021 Mar 29;4(1):427. PMID: 33782502.
    • Effect of enhanced aryl hydrocarbon receptor expression on inflammatory response and healing of alveolar bone defects in diabetic rats.
      Luo Yicai, Li Hao.
      Chinese Journal of Tissue Engineering Research, 2021, 25(14): 2166-2171.
    • Extracellular transglutaminase 2 induces myotube hypertrophy through G protein-coupled receptor 56.
      Kitakaze T, Yoshikawa M, Kobayashi Y, Kimura N, Goshima N, Ishikawa T, Ogata Y, Yamashita Y, Ashida H, Harada N, Yamaji R.
      Biochim Biophys Acta Mol Cell Res. 2020 Feb;1867(2):118563. PMID: 31666191
    • ROR2 blockade as a therapy for osteoarthritis.
      Thorup AS, Strachan D, Caxaria S, Poulet B, Thomas BL, Eldridge SE, Nalesso G, Whiteford JR, Pitzalis C, Aigner T, Corder R, Bertrand J, Dell'Accio F.
      Sci Transl Med. 2020 Sep 16;12(561):eaax3063. PMID: 32938794.
    • Wwp2 maintains cartilage homeostasis through regulation of Adamts5.
      Mokuda S, Nakamichi R, Matsuzaki T, Ito Y, Sato T, Miyata K, Inui M, Olmer M, Sugiyama E, Lotz M, Asahara H.
      Nat Commun. 2019 Jun 3;10(1):2429. PMID: 31160553
    • Dissociation of Systemic Glucose Homeostasis from Triacylglyceride Accumulation by Reduced Acsl6 Expression in Skeletal Muscle.
      Lee, J.Y., Kim, AR., Jung, YH. et al.
      Biotechnol Bioproc E (2018) 23(4): 465-472.
    • Effects of Co-Transfection with Myostatin-Targeting siRNA and ActRIIB-Fc Fusion Protein on Skeletal Muscle Growth.
      Od BAYARSAIKHAN, Nobuhiko KAWAI, Hiroyo MORI, Nao KINOUCHI, Takeshi NIKAWA, Eiji TANAKA
      Journal of Oral Health and Biosciences Vol. 30 (2017) No. 1 p. 1-7
    • lncRNA Chronos is an aging-induced inhibitor of muscle hypertrophy.
      Neppl RL, Wu CL, Walsh K.
      J Cell Biol. 2017 Nov 6;216(11):3497-3507. PMID: 28855249
    • AAA-ATPase p97 suppresses apoptotic and autophagy-associated cell death in rheumatoid arthritis synovial fibroblasts.
      Kato M, Ospelt C, Kolling C, Shimizu T, Kono M, Yasuda S, Michel BA, Gay RE, Gay S, Klein K, Atsumi T.
      Oncotarget. 2016 Sep 27;7(39):64221-64232. PMID: 27623077
    • Inhibition of microRNA-222 expression accelerates bone healing with enhancement of osteogenesis, chondrogenesis, and angiogenesis in a rat refractory fracture model.
      Yoshizuka M, Nakasa T, Kawanishi Y, Hachisuka S, Furuta T, Miyaki S, Adachi N, Ochi M.
      J Orthop Sci. 2016 Nov;21(6):852-858. PMID: 27545451
    • Lentivirus-TAZ Administration Alleviates Osteoporotic Phenotypes in the Femoral Neck of Ovariectomized Rats.
      Zhang Y, Wang Z, Ding L, Damaolar A, Li Z, Qiu Y, Yin Z.
      Cell Physiol Biochem. 2016;38(1):283-94. PMID: 26800426
    • RasGRP4 is Aberrantly Expressed in the Fibroblast-like Synoviocytes of Patients with Rheumatoid Arthritis and Controls their Proliferation.
      Kono M, Yasuda S, Stevens RL, Koide H, Kurita T, Shimizu Y, Kanetsuka Y, Oku K, Bohgaki T, Amengual O, Horita T, Shimizu T, Majima T, Koike T, Atsumi T.
      Arthritis Rheumatol. 2015 Feb;67(2):396-407. PMID: 25330932
    • Female-specific regulation of skeletal muscle mass by USP19 in young mice.
      Ogawa M, Kitakaze T, Harada N, Yamaji R.
      J Endocrinol. 2015 Jun;225(3):135-45. PMID: 25901042
    • Acceleration of healing of the medial collateral ligament of the knee by local administration of synthetic microRNA-210 in a rat model.
      Muhammad Sakti, Tomoyuki Nakasa, Takeshi Shoji, Muhammad Andry Usman, Yoshitaka Kawanishi, Michio Hamanishi, Irawan Yusuf, Mitsuo Ochi.
      Asia-Pacific Journal of Sports Medicine, Arthroscopy, Rehabilitation and Technology, Volume 2, Issue 4, October 2015, Pages 129-136.
    • The effect of administration of double stranded MicroRNA-210 on acceleration of Achilles tendon healing in a rat model.
      Usman MA, Nakasa T, Shoji T, Kato T, Kawanishi Y, Hamanishi M, Kamei N, Ochi M.
      J Orthop Sci. 2015 May;20(3):538-46. PMID: 25753838
    • The CXCR4/SDF1 axis improves muscle regeneration through MMP-10 activity.
      Bobadilla M, Sáinz N, Abizanda G, Orbe J, Rodríguez JA, Páramo JA, Prósper F, Pérez-Ruiz A.
      Stem Cells Dev. 2014 Jun 15;23(12):1417-27. PMID: 24548137
    • Intra-articular injection of synthetic microRNA-210 accelerates avascular meniscal healing in rat medial meniscal injured model.
      Kawanishi Y, Nakasa T, Shoji T, Hamanishi M, Shimizu R, Kamei N, Usman M, Ochi M.
      Arthritis Res Ther. 2014 Nov 28;16(6):488. PMID: 25430980
    • Local Applications of Myostatin-siRNA with Atelocollagen Increase Skeletal Muscle Mass and Recovery of Muscle Function.
      Kawakami E, Kawai N, Kinouchi N, Mori H, Ohsawa Y, Ishimaru N, Sunada Y, Noji S, Tanaka E.
      PLoS One. 2013 May 22;8(5):e64719.PMID: 23717655　　
    • A small interfering RNA targeting Lnk accelerates bone fracture healing with early neovascularization.
      Kawakami Y, Ii M, Matsumoto T, Kawamoto A, Kuroda R, Akimaru H, Mifune Y, Shoji T, Fukui T, Asahi M, Kurosaka M, Asahara T.
      Lab Invest. 2013 Sep;93(9):1036-53. PMID: 23897412
    • Histone demethylase Jmjd3 regulates osteoblast differentiation via transcription factors Runx2 and Osterix.
      Yang D, Okamura H, Nakashima Y, Haneji T.
      J Biol Chem. 2013 Nov 22;288(47):33530-41. PMID: 24106268
    • The Effect of Intra-articular Injection of MicroRNA-210 on Ligament Healing in a Rat Model.
      Shoji T, Nakasa T, Yamasaki K, Kodama A, Miyaki S, Niimoto T, Okuhara A, Kamei N, Adachi N, Ochi M.
      Am J Sports Med. 2012 Nov;40(11):2470-8. PMID: 22986296
    • Acceleration of muscle regeneration by local injection of muscle-specific microRNAs in rat skeletal muscle injury model.
      Nakasa T, Ishikawa M, Shi M, Shibuya H, Adachi N, Ochi M.
      J Cell Mol Med. 2010 Oct;14(10):2495-505. PMID:19754672
    • Presenilin-1 acts via Id1 to regulate the function of muscle satellite cells in a gamma-secretase-independent manner.
      Ono Y, Gnocchi VF, Zammit PS, Nagatomi R.
      J Cell Sci. 2009 Dec 15;122(Pt 24):4427-38. PMID: 19920078
    • Induction of apoptosis in the synovium of mice with autoantibody-mediated arthritis by the intraarticular injection of double-stranded MicroRNA-15a.
      Nagata Y, Nakasa T, Mochizuki Y, Ishikawa M, Miyaki S, Shibuya H, Yamasaki K, Adachi N, Asahara H, Ochi M.
      Arthritis Rheum. 2009 Sep;60(9):2677-83. PMID:19714650
    • MicroRNA-148a Controls Epidermal and Hair Follicle Stem/Progenitor Cells by Modulating the Activities of ROCK1 and ELF5.
      Pickup ME, Hu A, Patel HJ, Ahmed MI.
      J Invest Dermatol. 2023 Mar;143(3):480-491.e5. PMID: 36116511.
    • The Contribution of LIGHT (TNFSF14) to the Development of Systemic Sclerosis by Modulating IL-6 and T Helper Type 1 Chemokine Expression in Dermal Fibroblasts.
      Ikawa T, Ichimura Y, Miyagawa T, Fukui Y, Toyama S, Omatsu J, Awaji K, Norimatsu Y, Watanabe Y, Yoshizaki A, Sato S, Asano Y.
      J Invest Dermatol. 2022 Jun;142(6):1541-1551.e3. PMID: 34838790.
    • Elevated Alpha 1(I) to Alpha 2(I) Collagen Ratio in Dermal Fibroblasts Possibly Contributes to Fibrosis in Systemic Sclerosis.
      Sawamura S, Makino K, Ide M, Shimada S, Kajihara I, Makino T, Jinnin M, Fukushima S.
      Int J Mol Sci. 2022 Jun 18;23(12):6811. PMID: 35743254.
    • Endothelial CCR6 expression due to FLI1 deficiency contributes to vasculopathy associated with systemic sclerosis.
      Ikawa T, Miyagawa T, Fukui Y, Toyama S, Omatsu J, Awaji K, Norimatsu Y, Watanabe Y, Yoshizaki A, Sato S, Asano Y.
      Arthritis Res Ther. 2021 Nov 13;23(1):283. PMID: 34774095
    • TGFβ promotes fibrosis by MYST1-dependent epigenetic regulation of autophagy.
      Zehender A, Li YN, Lin NY, Stefanica A, Nüchel J, Chen CW, Hsu HH, Zhu H, Ding X, Huang J, Shen L, Györfi AH, Soare A, Rauber S, Bergmann C, Ramming A, Plomann M, Eckes B, Schett G, Distler JHW.
      Nat Commun. 2021 Jul 20;12(1):4404. PMID: 34285225
    • TGFβ-induced epigenetic deregulation of SOCS3 facilitates STAT3-signaling to promote fibrosis.
      Dees C, Pötter S, Zhang Y, Bergmann C, Zhou X, Luber M, Wohlfahrt T, Karouzakis E, Ramming A, Gelse K, Yoshimura A, Jaenisch R, Distler O, Schett G, Distler JH.
      J Clin Invest. 2020 May 1;130(5):2347-2363. PMID: 31990678
    • Regulation of skin fibrosis by RALDH1-producing dermal dendritic cells via retinoic acid-mediated regulatory T cell induction: A role in scleroderma.
      Miura S, Asano Y, Saigusa R, Yamashita T, Taniguchi T, Takahashi T, Ichimura Y, Toyama T, Yoshizaki A, Sato S, Kadono T.
      J Dermatol Sci. 2020 Feb;97(2):125-134. PMID: 31959382
    • Targeting of NADPH oxidase in vitro and in vivo suppresses fibroblast activation and experimental skin fibrosis.
      Dosoki H, Stegemann A, Taha M, Schnittler H, Luger TA, Schröder K, Distler JH, Kerkhoff C, Böhm M.
      Exp Dermatol. 2017 Jan;26(1):73-81. PMID: 27576129
    • Tribbles homologue 3 stimulates canonical TGF-β signalling to regulate fibroblast activation and tissue fibrosis.
      Tomcik M, Palumbo-Zerr K, Zerr P, Sumova B, Avouac J, Dees C, Distler A, Becvar R, Distler O, Schett G, Senolt L, Distler JH.
      Ann Rheum Dis. 2016 Mar;75(3):609-16. PMID: 25603829
    • Inactivation of evenness interrupted (EVI) reduces experimental fibrosis by combined inhibition of canonical and non-canonical Wnt signalling.
      Distler A, Ziemer C, Beyer C, Lin NY, Chen CW, Palumbo-Zerr K, Dees C, Weidemann A, Distler O, Schett G, Distler JH.
      Ann Rheum Dis. 2014 Mar 1;73(3):624-7. PMID: 24257024
    • Inactivation of tankyrases reduces experimental fibrosis by inhibiting canonical Wnt signalling.
      Distler A, Deloch L, Huang J, Dees C, Lin NY, Palumbo-Zerr K, Beyer C, Weidemann A, Distler O, Schett G, Distler JH.
      Ann Rheum Dis. 2013 Sep 1;72(9):1575-80. PMID: 23148305
    • Inhibition of hedgehog signalling prevents experimental fibrosis and induces regression of established fibrosis
      Horn A, Kireva T, Palumbo-Zerr K, Dees C, Tomcik M, Cordazzo C, Zerr P, Akhmetshina A, Ruat M, Distler O, Beyer C, Schett G, Distler JH.
      Ann Rheum Dis 2012;71:785-789 PMID:22402139
    • Inhibition of sumoylation prevents experimental fibrosis.
      Khodzhigorova A, Akhmetshina A, Lang V, Dees C, Schneider H, Beyer C, Gelse K, Distler O, Schett G, Distler JH.
      Ann Rheum Dis. 2012 Nov;71(11):1904-8. PMID:22904261
    • Endogenous Interleukin-1β Is Implicated in Intraplaque Hemorrhage in Apolipoprotein E Gene Null Mice.
      Suzuki E, Imuta H, Fujita D, Takahashi M, Oba S, Kiyosue A, Nishimatsu H.
      Circ J. 2018 Mar 23;82(4):1130-1138. PMID: 29467356
    • Down-regulation of Fibulin-5 is associated with aortic dilation: role of inflammation and epigenetics.
      Orriols M, Varona S, Martí-Pàmies I, Galán M, Guadall A, Escudero JR, Martín-Ventura JL, Camacho M, Vila L, Martínez-González J, Rodríguez C.
      Cardiovasc Res. 2016 Jun 1;110(3):431-42. PMID: 27089918
    • Functional MMP-10 is required for efficient tissue repair after experimental hind limb ischemia.
      Gomez-Rodriguez V, Orbe J, Martinez-Aguilar E, Rodriguez JA, Fernandez-Alonso L, Serneels J, Bobadilla M, Perez-Ruiz A, Collantes M, Mazzone M, Paramo JA, Roncal C.
      FASEB J. 2015 Mar;29(3):960-72. PMID: 25414484
    • Role of Girdin in intimal hyperplasia in vein grafts and efficacy of atelocollagen-mediated application of small interfering RNA for vein graft failure.
      Miyachi H, Mii S, Enomoto A, Murakumo Y, Kato T, Asai N, Komori K, Takahashi M.
      J Vasc Surg. 2014 Aug;60(2):479-489.e5. PMID: 23948670
    • Inhibition of Neuregulin-1/ErbB Signaling in the Rostral Ventrolateral Medulla Leads to Hypertension through Reduced Nitric Oxide Synthesis
      Matsukawa R, Hirooka Y, Ito K, Sunagawa K.
      Am J Hypertens. 2013 Jan;26(1):51-7. PMID: 23382327
    • Neuregulin-1/ErbB signaling in rostral ventrolateral medulla is involved in blood pressure regulation as an antihypertensive system.
      Matsukawa R, Hirooka Y, Nishihara M, Ito K, Sunagawa K.
      J Hypertens. 2011 Sep;29(9):1735-42. PMID:21738056
    • Controlled release of small interfering RNA targeting midkine attenuates intimal hyperplasia in vein grafts.
      Banno H, Takei Y, Muramatsu T, Komori K, Kadomatsu K.
      J Vasc Surg. 2006 Sep;44(3):633-41. PMID:16950446
    • Supplement of tetrahydrobiopterin by a gene transfer of GTP cyclohydrolase I cDNA improves vascular dysfunction in insulin-resistant rats.
      Shinozaki K, Nishio Y, Yoshida Y, Koya D, Ayajiki K, Masada M, Kashiwagi A, Okamura T.
      J Cardiovasc Pharmacol. 2005 Oct;46(4):505-12. PMID:16160605
    • Identification of drug transporters contributing to oxaliplatin-induced peripheral neuropathy.
      Fujita S, Hirota T, Sakiyama R, Baba M, Ieiri I.
      J Neurochem. 2019 Feb;148(3):373-385. PMID: 30295925
    • Intrathecal miR-96 inhibits Nav1.3 expression and alleviates neuropathic pain in rat following chronic construction injury.
      Chen HP, Zhou W, Kang LM, Yan H, Zhang L, Xu BH, Cai WH.
      Neurochem Res. 2014 Jan;39(1):76-83. PMID: 24234845
    • Chondroitin sulphate N-acetylgalactosaminyl-transferase-1 inhibits recovery from neural injury.
      Takeuchi K, Yoshioka N, Higa Onaga S, Watanabe Y, Miyata S, Wada Y, Kudo C, Okada M, Ohko K, Oda K, Sato T, Yokoyama M, Matsushita N, Nakamura M, Okano H, Sakimura K, Kawano H, Kitagawa H, Igarashi M.
      Nat Commun. 2013;4:2740. PMID: 24220492
    • Photomechanical Wave-Driven Delivery of siRNAs Targeting Intermediate Filament Proteins Promotes Functional Recovery after Spinal Cord Injury in Rats
      Takahiro Ando, Shunichi Sato mail, Terushige Toyooka, Hiroaki Kobayashi, Hiroshi Nawashiro, Hiroshi Ashida, Minoru Obara.
      PLoS One. 2012;7(12):e51744. PMID: 20181596
    • Down-regulation of glial fibrillary acidic protein and vimentin by RNA interference improves acute urinary dysfunction associated with spinal cord injury in rats.
      Toyooka T, Nawashiro H, Shinomiya N, Shima K.
      J Neurotrauma. 2011 Apr;28(4):607-18. PMID:21250919
    • An siRNA against JC virus (JCV) agnoprotein inhibits JCV infection in JCV-producing cells inoculated in nude mice.
      Matoba T, Orba Y, Suzuki T, Makino Y, Shichinohe H, Kuroda S, Ochiya T, Itoh H, Tanaka S, Nagashima K, Sawa H.
      Neuropathology. 2008 Jun;28(3):286-94. PMID:18179406
    • Transient receptor potential ankyrin 1 channels in the bladder mediate low temperature elicited bladder overactivity in rats.
      Imamura T, Ogawa T, Minagawa T, Daimon H, Nagai T, Ueno M, Saito T, Ishizuka O.
      Neurourol Urodyn. 2024 Jan;43(1):276-288. PMID: 38010891.
    • The Role of microRNAs Related to Apoptosis for N-Methyl-d-Aspartic Acid-Induced Neuronal Cell Death in the Murine Retina.
      Sone K, Mori A, Sakamoto K, Nakahara T.
      Int J Mol Sci. 2024 Jan 16;25(2):1106. PMID: 38256177.
    • Tie1 contributes to the development of ovarian hyperstimulation syndrome under the regulation of EGR1 in granulosa cells.
      Sun L, Tian H, Xue S, Ye H, Xue X, Wang R, Liu Y, Zhang C, Chen Q, Gao S.
      Exp Mol Med. 2022 Jan;54(1):81-90. PMID: 35079118.
    • The matrix vesicle cargo miR-125b accumulates in the bone matrix, inhibiting bone resorption in mice.
      Minamizaki T, Nakao Y, Irie Y, Ahmed F, Itoh S, Sarmin N, Yoshioka H, Nobukiyo A, Fujimoto C, Niida S, Sotomaru Y, Tanimoto K, Kozai K, Sugiyama T, Bonnelye E, Takei Y, Yoshiko Y.
      Commun Biol. 2020 Jan 16;3(1):30. PMID: 31949279
    • Suppression of NLRP3 inflammasome improves alveolar bone defect healing in diabetic rats.
      Li H, Zhong X, Chen Z, Li W.
      J Orthop Surg Res. 2019 May 30;14(1):167. PMID: 31146750
    • Theobromine suppresses adipogenesis through enhancement of CCAAT-enhancer-binding protein β degradation by adenosine receptor A1.
      Mitani T, Watanabe S, Yoshioka Y, Katayama S, Nakamura S, Ashida H.
      Biochim Biophys Acta. 2017 Sep 28;1864(12):2438-2448. PMID: 28965824
    • PACAP suppresses dry eye signs by stimulating tear secretion.
      Nakamachi T, Ohtaki H, Seki T, Yofu S, Kagami N, Hashimoto H, Shintani N, Baba A, Mark L, Lanekoff I, Kiss P, Farkas J, Reglodi D, Shioda S.
      Nat Commun. 2016 Jun 27;7:12034. PMID: 27345595
    • Protein S exacerbates alcoholic hepatitis by stimulating liver natural killer T cells.
      Chelakkot-Govindalayathil AL, Mifuji-Moroka R, D'Alessandro-Gabazza CN, Toda M, Matsuda Y, Gil-Bernabe P, Roeen Z, Yasuma T, Yano Y, Gabazza EC, Iwasa M, Takei Y.
      J Thromb Haemost. 2015 Jan;13(1):142-54. PMID: 25399514
    • Attenuated AMH signaling pathway plays an important role in the pathogenesis of ovarian hyperstimulation syndrome.
      Wang L, Li H, Ai J, Yue J, Li Z, Zhang H, Zhao Y.
      Am J Transl Res. 2015 Oct 15;7(10):1925-38.
    • A critical role for thymic stromal lymphopoietin in nickel-induced allergy in mice.
      Ashrin MN, Arakaki R, Yamada A, Kondo T, Kurosawa M, Kudo Y, Watanabe M, Ichikawa T, Hayashi Y, Ishimaru N.
      J Immunol. 2014 May 1;192(9):4025-31. PMID: 24670797
    • Osteopontin knockdown in the kidneys of hyperoxaluric rats leads to reduction in renal calcium oxalate crystal deposition.
      Tsuji H, Shimizu N, Nozawa M, Umekawa T, Yoshimura K, De Velasco MA, Uemura H, Khan SR.
      Urolithiasis. 2014 Jun;42(3):195-202. PMID: 24619192
    • Regulation of mucosal mast cell activation by short interfering RNAs targeting syntaxin4.
      Liu S, Nugroho AE, Shudou M, Maeyama K.
      Immunol Cell Biol. 2012 Mar;90(3):337-45. PMID:21625250
    • Targeted suppression of HO-2 gene expression impairs the innate anti-inflammatory and repair responses of the cornea to injury.
      Bellner L, Patil KA, Castellano K, Halilovic A, Dunn MW, Schwartzman ML.
      Mol Vis. 2011 Apr 29;17:1144-52. PMID:21552471
    • A novel DC therapy with manipulation of MKK6 gene on nickel allergy in mice.
      Watanabe M, Ishimaru N, Ashrin MN, Arakaki R, Yamada A, Ichikawa T, Hayashi Y.
      PLoS One. 2011 Apr 22;6(4):e19017. PMID:21544193
    • Targeted conversion of the transthyretin gene in vitro and in vivo.
      Nakamura M, Ando Y, Nagahara S, Sano A, Ochiya T, Maeda S, Kawaji T, Ogawa M, Hirata A, Terazaki H, Haraoka K, Tanihara H, Ueda M, Uchino M, Yamamura K.
      Gene Ther. 2004 May;11(10):838-46. PMID:14961068
    • Biomaterials for gene delivery: atelocollagen-mediated controlled release of molecular medicines.
      Ochiya T, Nagahara S, Sano A, Itoh H, Terada M.
      Curr Gene Ther. 2001 May;1(1):31-52. PMID:12109137