Atelocollagen Sponge MIGHTY | KOKEN CO., LTD. | KOKEN CO., LTD.

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Atelocollagen Sponge, MIGHTY


Atelocollagen sponge MIGHTY consists primarily of type I atelocollagen derived from bovine dermis and can withstand compressive loadings of up to 40 kPa. Culturing cells in MIGHTY under cyclic compressive loading simulates the in vivo environment for evaluating cell function. MIGHTY is also useful as a scaffold for  3D culture.

What is Atelocollagen?


  • 3D culture

  • Mechanical stress culture

  • Cell transplantation

  • Sustained-release of bioactive compounds


  • Retains structural rigidity during repeated compressive loadings of 40 kPa.

  • Sized for 96-well plates.

  • It is biodegradable and suitable for cell transplantation

Type of collagen

Bovine dermis derived atelocollagen

  • Cross-sectional view of an SEM image of MIGHTY

  • Cross-sectional view image of NIH3T3 fibroblasts, seeded in a MIGHTY
    (live cell imaging by fluorescence microscopy)

Cat. No. Product Packaging Price
CSM-25 Atelocollagen Sponge, MIGHTY Sterilized
25 pcs/bottle Visit distributor’s
web page
CSM-50 Atelocollagen Sponge, MIGHTY Sterilized
50 pcs/bottle Visit distributor’s
web page

Storage: Room temperature  For research use only.

Click here for frequently asked questions about MIGHTY


  • Bone, Cartilage
  • Skin, Miscellaneous
    • Effect of the combined use of enamel matrix derivative and atelocollagen sponge scaffold on osteoblastic differentiation of mouse induced pluripotent stem cells in vitro.
      Hisanaga Y, Suzuki E, Aoki H, Sato M, Saito A, Saito A, Azuma T.
      J Periodontal Res. 2018 Apr;53(2):240-249. PMID: 29044527
    • Elevated expression of Dkk-1 by glucocorticoid treatment impairs bone regenerative capacity of adipose tissue-derived mesenchymal stem cells.
      Kato T, Khanh VC, Sato K, Kimura K, Yamashita T, Sugaya H, Yoshioka T, Mishima H, Ohneda O.
      Stem Cells Dev. 2018 Jan 15;27(2):85-99. PMID: 29084466
    • Effect of cyclic compressive loading on redifferentiation of human chondrocytes in three-dimensional cultured tissue.
      Tomoko Okamoto, Kenji Kakudo, Yuichi Ohnishi, Masahiro Nakajima, Ken nakata
      J Osaka Dent Univ. 2017 (April);51(1), 23-30.
    • Three-dimensional system enabling the maintenance and directed differentiation of pluripotent stem cells under defined conditions.
      Zujur D, Kanke K, Lichtler AC, Hojo H, Chung UI, Ohba S.
      Sci Adv. 2017 May 12;3(5):e1602875. PMID: 28508073
    • Osteogenic potential of recombinant human bone morphogenetic protein-9/absorbable collagen sponge (rhBMP-9/ACS) in rat critical size calvarial defects.
      Nakamura T, Shirakata Y, Shinohara Y, Miron RJ, Furue K, Noguchi K.
      Clin Oral Investig. 2017 Jun;21(5):1659-1665. PMID: 27726024
    • Bone healing capabilities of recombinant human bone morphogenetic protein-9 (rhBMP-9) with a chitosan or collagen carrier in rat calvarial defects.
      Shinohara Y, Nakamura T, Shirakata Y, Noguchi K.
      Dent Mater J. 2016;35(3):454-60. PMID: 27252002
    • Bone formation by human umbilical cord perivascular cells.
      Kajiyama S, Ujiie Y, Nishikawa S, Inoue K, Shirakawa S, Hanada N, Liddell R, Davies JE, Gomi K.
      J Biomed Mater Res A. 2015 Aug;103(8):2807-14. PMID: 25676366
    • Chondrocyte differentiation of human buccal fat pad-derived dedifferentiated fat cells and adipose stem cells using an atelocollagen sponge.
      Nishio Akihiro, Kubo Hirohito, Kishimoto Naotaka, Hashimoto Yoshiya, Kakudo Kenji.
      J Osaka Dent Univ. 2015 (October);49(2), 185-196.
    • Celecoxib down-regulates mechanically induced ADAMTS-4 gene expression in 3D cultured tissue of human synovium-derived cells at lower concentration than indomethacin.
      M Kondo, K Nakata, K Kakudo.
      J Osaka Dent Univ. 2014 April; 48(1), 55-59.
    • Biodistribution of locally or systemically transplanted osteoblast-like cells.
      Okabe YT, Kondo T, Mishima K, Hayase Y, Kato K, Mizuno M, Ishiguro N, Kitoh H.
      Bone Joint Res. 2014 Mar 20;3(3):76-81. PMID: 24652780
    • Cyclic compressive loading on 3D tissue of human synovial fibroblasts upregulates prostaglandin E2 via COX-2 production without IL-1β and TNF-α.
      Shimomura K, Kanamoto T, Kita K, Akamine Y, Nakamura N, Mae T, Yoshikawa H, Nakata K.
      Bone Joint Res. 2014 Sep;3(9):280-8. PMID: 25237168
    • Optimal cyclic compressive loading promotes differentiation of 3D-cultured pre-osteoblasts.
      K Ota, Y Muroi, K Kakudo, K Nakata.
      J Osaka Dent Univ. 2013 (April);47(1):117-125.
    • Enhanced in vivo osteogenesis by nanocarrier-fused bone morphogenetic protein-4.
      Shiozaki Y, Kitajima T, Mazaki T, Yoshida A, Tanaka M, Umezawa A, Nakamura M, Yoshida Y, Ito Y, Ozaki T, Matsukawa A.
      Int J Nanomedicine. 2013;8:1349-60. PMID: 23630418
    • Prolonged matrix metalloproteinase-3 high expression after cyclic compressive load on human synovial cells in three-dimensional cultured
      Akamine Y, Kakudo K, Kondo M, Ota K, Muroi Y, Yoshikawa H, Nakata K.
      Int J Oral Maxillofac Surg. 2012 Jul;41(7):874-81. PMID:22264498
    • Effects of Compressive Loading on Human Synovium-derived cells.
      Muroi Y, Kakudo K, Nakata K.
      J Dent Res. 2007 Aug;86(8):786-91. PMID: 17652211
    • A study on optimum orthodontic force using human periodontal ligament cells on 3D culture system.
      Meri Haniu, Takenori Kim, Yoshiaki Satho and Junichiro Ida.
      Hokkaido J. Dent. Sci., 34:97-105,2014.
    • Tumor associated osteoclast-like giant cells promote tumor growth and lymphangiogenesis by secreting vascular endothelial growth factor-C.
      Hatano Y, Nakahama KI, Isobe M, Morita I.
      Biochem Biophys Res Commun. 2014 Mar 28;446(1):149-54. PMID: 24607909
    • Effect of strain on human dermal fibroblasts in a three-dimensional collagen sponge.
      Hara M, Fujii T, Hashizume R, Nomura Y.
      Cytotechnology. 2014 Oct;66(5):723-8. PMID: 24096838
    • Biological responses of three-dimensional cultured fibroblasts by sustained compressive loading include apoptosis and survival activity.
      Kanazawa T, Nakagami G, Minematsu T, Yamane T, Huang L, Mugita Y, Noguchi H, Mori T, Sanada H.
      PLoS One. 2014 Aug 7;9(8):e104676. PMID: 25102054