AteloGene® Local Use for in vivo transfection | KOKEN CO., LTD. | KOKEN CO., LTD.

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AteloGene® Local Use


Click here for improved product, AteloGene® Local Use “Quick Gelation”

This in vivo transfection kit is designed for delivering siRNA/miRNA into animal tissues, mouse in particular, to introduce the siRNA/miRNA into cells by local administrations.
Atelocollagen is positively charged and can thus electrostatically form complexes with nucleic acids when they are mixed together at appropriate concentrations and ratios. The complexes protect nucleic acids from being degraded by nucleases in in vivo.

What is Atelocollagen?


Local administration of nucleic acids


  • Prolonged in vivo RNAi effect because atelocollagen, the main component of AteloGene® products, form complexes with siRNA/miRNA
  • Since AteloGene® products are made from atelocollagen, it is nontoxic.
  • AteloGene® Local Use gelates in the body and siRNA/miRNA are slowly released from the gel at the site of administration.

Kit contents

① AteloGene® Local Use prefilled syringe
 (Including losses during the preparation steps)
600 μL × 2 syringes
②10×siRNA buffer
(It can be used for miRNA as well)
3 mL × 1 bottle
③Sterilized water 3 mL × 1 bottle
④2 mL microtube 2 tubes
⑤Disposable Syringe 2 tubes
⑥18G needle 4 needles
⑦26G needle 2 tubes
⑧Instruction manual 1 leaflet


Devices and reagents required other than those in the kit

  • siRNA/miRNA (PAGE- or HPLC-purified grade is recommended.)
  • Container for preparation of siRNA/miRNA solution (sterilized, RNase-free)
  • Cooling device (crushed ice, cold block, etc.)
  • Tube rotator (that can tumble and agitate such as TAITEC RT-5, Bibby scientific SB3, etc.)
  • Pipetter and tips (sterilized, RNase-free)
  • High-speed refrigerated centrifuge
  • Anesthetic
Cat. No. Product Package Price
for Cosmo Bio customers

for REPROCELL customers

AteloGene® Local Use 1 kit
(10 administrations) *
Visit distributor’s
web page

*It can be used more than 10 administrations depending on target tissue because one administration is assumed to be 200μl.

Storage: 2-10°C  For research use only.
Expiration date: 5 years from manufacturing date printed on the box.

Click here for frequently asked questions about AteloGene® Local Use

Experimental example

Local siRNA administration to mouse xenograft model with AteloGene® Local Use

After local administration of a luciferase siRNA (Luc siRNA) & AteloGene® mixture to subcutaneous tumours expressing luciferase, luciferase expression was markedly reduced when compared to the control.


  • Local administration in Cancer research
  • Local administration in other research
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      Fujii R, Osaka E, Sato K, Tokuhashi Y.
      Cancer Genomics Proteomics. 2019 Jan-Feb;16(1):71-79. PMID: 30587501
    • Augmented antitumor activity of 5-fluorouracil by double knockdown of MDM4 and MDM2 in colon and gastric cancer cells.
      Imanishi M, Yamamoto Y, Wang X, Sugaya A, Hirose M, Endo S, Natori Y, Yamato K, Hyodo I.
      Cancer Sci. 2019 Feb;110(2):639-649. PMID: 30488540.
    • Low levels of tumour suppressor miR-655 in plasma contribute to lymphatic progression and poor outcomes in oesophageal squamous cell carcinoma.
      Kiuchi J, Komatsu S, Imamura T, Nishibeppu K, Shoda K, Arita T, Kosuga T, Konishi H, Shiozaki A, Okamoto K, Fujiwara H, Ichikawa D, Otsuji E.
      Mol Cancer. 2019 Jan 4;18(1):2. PMID: 30609933
    • Absence of Cytosolic 2-Cys Prx Subtypes I and II Exacerbates TNF-α-Induced Apoptosis via Different Routes.
      Lee S, Lee JY, Lee EW, Park S, Kang DH, Min C, Lee DJ, Kang D, Song J, Kwon J, Kang SW.
      Cell Rep. 2019 Feb 19;26(8):2194-2211.e6. PMID: 30784599
    • The long noncoding RNA HORAS5 mediates castration-resistant prostate cancer survival by activating the androgen receptor transcriptional program.
      Parolia A, Venalainen E, Xue H, Mather R, Lin D, Wu R, Pucci P, Rogalski J, Evans JR, Feng F, Collins CC, Wang Y, Crea F.
      Mol Oncol. 2019 May;13(5):1121-1136. PMID: 30776192
    • Cadherin 11 Inhibition Downregulates β-catenin, Deactivates the Canonical WNT Signalling Pathway and Suppresses the Cancer Stem Cell-Like Phenotype of Triple Negative Breast Cancer.
      Satriyo PB, Bamodu OA, Chen JH, Aryandono T, Haryana SM, Yeh CT Chao TY.
      J Clin Med. 2019 Jan 27;8(2). pii: E148. PMID: 30691241
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      Mizoguchi A, Takayama A, Arai T, Kawauchi J, Sudo H.
      PLoS One. 2018 Dec 27;13(12):e0209750. PMID: 30589909 .
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      Cell Death Differ. 2019 Jan;26(2):245-259. PMID: 29786073
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      Cell Death Dis. 2018 Aug 1;9(8):826. PMID: 30069008
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      Sci Rep. 2018 Mar 14;8(1):4482. PMID: 29540837
    • Depleted tumor suppressor miR-107 in plasma relates to tumor progression and is a novel therapeutic target in pancreatic cancer
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      Int J Oncol. 2017 May;50(5):1634-1646. PMID: 28339026
    • Ephrin-B2 reverse signaling regulates progression and lymph node metastasis of oral squamous cell carcinoma.
      Sasabe E, Tomomura A, Tomita R, Sento S, Kitamura N, Yamamoto T.
      PLoS One. 2017 Nov 30;12(11):e0188965. PMID: 29190834
    • The microRNA miR-516a-3p regulates the Wnt pathway by targeting extracellular sulfatase 1
      in human scirrhous gastric cancers: Anti-metastatic therapy via miRNA-based medicine
      Yoshifumi Takei, Akiko Suzuki, Keichiro Mihara, Kazuyoshi Yanagihara
      Medical Research Archives, Vol. 5, Issue 7, July 2017
    • ANKRD22 promotes progression of non-small cell lung cancer through transcriptional up-regulation of E2F1.
      Yin J, Fu W, Dai L, Jiang Z, Liao H, Chen W, Pan L, Zhao J.
      Sci Rep. 2017 Jun 30;7(1):4430. PMID: 28667340
    • Oncogenic role of rab escort protein 1 through EGFR and STAT3 pathway.
      Yun UJ, Sung JY, Park SY, Ye SK, Shim J, Lee JS, Hibi M, Bae YK, Kim YN.
      Cell Death Dis. 2017 Feb 23;8(2):e2621. PMID: 28230863
    • Pharmacological regulation of bladder cancer by miR-130 family seed-targeting LNA.
      Egawa H, Jingushi K, Hirono T, Hirose R, Nakatsuji Y, et al.
      (2016) Integr Mol Med. Volume 3(1): 457-463.
    • Nek2 siRNA therapy using a portal venous port-catheter system for liver metastasis in pancreatic cancer.
      Kokuryo T, Hibino S, Suzuki K, Watanabe K, Yokoyama Y, Nagino M, Senga T, Hamaguchi M.
      Cancer Sci. 2016 Sep;107(9):1315-20. PMID: 27316377
    • A therapeutic trial of human melanomas with combined small interfering RNAs targeting adaptor molecules p130Cas and paxillin activated under expression of ganglioside GD3.
      Makino Y, Hamamura K, Takei Y, Bhuiyan RH, Ohkawa Y, Ohmi Y, Nakashima H, Furukawa K, Furukawa K.
      Biochim Biophys Acta. 2016 Aug;1860(8):1753-63. PMID: 27068854
    • Docetaxel induced-JNK2/PHD1 signaling pathway increases degradation of HIF-1α and causes cancer cell death under hypoxia.
      Oh ET, Kim CW, Kim SJ, Lee JS, Hong SS, Park HJ.
      Sci Rep. 2016 Jun 6;6:27382. PMID: 27263528
    • Unfavorable neuroblastoma prognostic factor NLRR2 inhibits cell differentiation by transcriptional induction through JNK pathway.
      Sheikh A, Takatori A, Hossain MS, Hasan MK, Tagawa M, Nagase H, Nakagawara A.
      Cancer Sci. 2016 Sep;107(9):1223-32. PMID: 27357360
    • Regulation of SLD5 gene expression by miR-370 during acute growth of cancer cells.
      Yamane K, Naito H, Wakabayashi T, Yoshida H, Muramatsu F, Iba T, Kidoya H, Takakura N.
      Sci Rep. 2016 Aug 8;6:30941. PMID: 27499248
    • Usefulness of microRNA‑375 as a prognostic and therapeutic tool in esophageal squamous cell carcinoma.
      Isozaki, Y., Hoshino, I., Akutsu, Y., Hanari, N., Mori, M., Nishimori, T., Murakami, K., Akanuma, N., Takeshita, N., Maruyama, T., Toyozumi, T., Takahashi, M., Suito, H., & Matsubara, H.
      Int J Oncol. 2015 Mar;46(3):1059-66. PMID: 25501018
    • Arl4c expression in colorectal and lung cancers promotes tumorigenesis and may represent a novel therapeutic target.
      Fujii S, Matsumoto S, Nojima S, Morii E, Kikuchi A.
      Oncogene. 2015 Sep 10;34(37):4834-44. PMID: 25486429
    • MiR-634 activates the mitochondrial apoptosis pathway and enhances chemotherapy-induced cytotoxicity.
      Fujiwara N, Inoue J, Kawano T, Tanimoto K, Kozaki KI, Inazawa J.
      Cancer Res. 2015 Sep 15;75(18):3890-901. PMID: 26216549
    • RFPL4A increases the G1 population and decreases sensitivity to chemotherapy in human colorectal cancer cells.
      Naito A, Yamamoto H, Kagawa Y, Naito Y, Okuzaki D, Otani K, Iwamoto Y, Maeda S, Kikuta J, Nishikawa K, Uemura M, Nishimura J, Hata T, Takemasa I, Mizushima T, Ishii H, Doki Y, Mori M, Ishii M.
      J Biol Chem. 2015 Mar 6;290(10):6326-37. PMID: 25605732
    • Efficient inhibition of tumor angiogenesis and growth by a synthetic peptide blocking S100A4-methionine aminopeptidase 2 interaction.
      Ochiya T, Takenaga K, Asagiri M, Nakano K, Satoh H, Watanabe T,
      Imajoh-Ohmi S, Endo H.
      Mol Ther Methods Clin Dev. 2015 Apr 1;2:15008. PMID: 26029719
    • Ubiquilin 2 enhances osteosarcoma progression through resistance to hypoxic stress.
      Tsukamoto S, Shimada K, Honoki K, Kido A, Akahane M, Tanaka Y, Konishi N.
      Oncol Rep. 2015 Apr;33(4):1799-806. PMID: 25672654
    • APOBEC3B-Mediated Cytidine Deamination Is Required for Estrogen Receptor Action in Breast Cancer.
      Periyasamy M, Patel H, Lai CF, Nguyen VT, Nevedomskaya E, Harrod A, Russell R, Remenyi J, Ochocka AM, Thomas RS, Fuller-Pace F, Győrffy B, Caldas C, Navaratnam N, Carroll JS, Zwart W, Coombes RC, Magnani L, Buluwela L, Ali S.
      Cell Rep. 2015 Oct 6;13(1):108-21. PMID: 26411678
    • Aurora kinase A has a significant role as a therapeutic target and clinical biomarker in endometrial cancer.
      Umene K, Yanokura M, Banno K, Irie H, Adachi M, Iida M, Nakamura K, Nogami Y, Masuda K, Kobayashi Y, Tominaga E, Aoki D.
      Int J Oncol. 2015 Apr;46(4):1498-506. PMID: 25625960
    • Glyoxalase I is differentially expressed in cutaneous neoplasms and contributes to the progression of squamous cell carcinoma.
      Zou XY, Ding D, Zhan N, Liu XM, Pan C, Xia YM.
      J Invest Dermatol. 2015 Feb;135(2):589-98. PMID: 25184957
    • RNA interference against cancer/testis genes identifies DUSP21 as a potential therapeutic target in human hepatocellular carcinoma.
      Deng Q, Li KY, Chen H, Dai JH, Zhai YY, Wang Q, Li N, Wang YP, Han ZG.
      Hepatology. 2014 Feb;59(2):518-30. PMID: 23929653
    • MicroRNAs cooperatively inhibit a network of tumor suppressor genes to promote pancreatic tumor growth and progression.
      Frampton AE, Castellano L, Colombo T, Giovannetti E, Krell J, Jacob J, Pellegrino L, Roca-Alonso L, Funel N, Gall TM, De Giorgio A, Pinho FG, Fulci V, Britton DJ, Ahmad R, Habib NA, Coombes RC, Harding V, Knösel T, Stebbing J, Jiao LR.
      Gastroenterology. 2014 Jan;146(1):268-77.e18. PMID: 24120476
    • Guanine nucleotide-binding protein 1 is one of the key molecules contributing to cancer cell radioresistance.
      Fukumoto M, Amanuma T, Kuwahara Y, Shimura T, Suzuki M, Mori S, Kumamoto H, Saito Y, Ohkubo Y, Duan Z, Sano K, Oguchi T, Kainuma K, Usami S, Kinoshita K, Lee I, Fukumoto M.
      Cancer Sci. 2014 Oct;105(10):1351-9. PMID: 25098609
    • Paired box 2 upregulates androgen receptor gene expression in androgen-independent prostate cancer.
      Ito S, Ueda T, Ueno A, Nakagawa H, Taniguchi H, Hongo F, Kamoi K, Okihara K, Kawauchi A, Miki T.
      FEBS J. 2014 Oct;281(19):4506-18. PMID: 25132193
    • High expression of protein tyrosine kinase 7 significantly associates with invasiveness and poor prognosis in intrahepatic cholangiocarcinoma.
      Jin J, Ryu HS, Lee KB, Jang JJ.
      PLoS One. 2014 Feb 28;9(2):e90247. PMID: 24587299
    • Significant involvement of herpesvirus entry mediator in human esophageal squamous cell carcinoma.
      Migita K, Sho M, Shimada K, Yasuda S, Yamato I, Takayama T, Matsumoto S, Wakatsuki K, Hotta K, Tanaka T, Ito M, Konishi N, Nakajima Y.
      Cancer. 2014 Mar 15;120(6):808-17. PMID: 24249528
    • Targeting CB2-GPR55 Receptor Heteromers Modulates Cancer Cell Signaling.
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    • AFAP1L1, a novel associating partner with vinculin, modulates cellular morphology and motility, and promotes the progression of colorectal cancers.
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    • Chondroitin sulphate N-acetylgalactosaminyl-transferase-1 inhibits recovery from neural injury.
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    • Potential of tumor-suppressive miR-596 targeting LGALS3BP as a therapeutic agent in oral cancer.
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    • Y-box binding protein-1 regulates cell proliferation and is associated with clinical outcomes of osteosarcoma.
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    • Ubiquitin C-terminal Hydrolase L1 (UCH-L1) Acts as a Novel Potentiator of Cyclin-dependent Kinases to Enhance Cell Proliferation, Independent of its Hydrolase Activity.
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    • Targeting the Vav3 oncogene enhances docetaxel-induced apoptosis through the inhibition of androgen receptor phosphorylation in LNCaP prostate cancer cells under chronic hypoxia.
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    • Up-regulation of endogenous PML induced by a combination of interferon-beta and temozolomide enhances p73/YAP-mediated apoptosis in glioblastoma.
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    • D-amino acid oxidase gene therapy sensitizes glioma cells to the antiglycolytic effect of 3-bromopyruvate.
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    • ALKBH3 contributes to survival and angiogenesis of human urothelial carcinoma cells through NADPH oxidase and Tweak/Fn14/VEGF signals.
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    • ZDHHC8 knockdown enhances radiosensitivity and suppresses tumor growth in a mesothelioma mouse model.
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      Cancer Sci. 2012 Feb;103(2):203-9. PMID:22017350
    • Therapeutic Potential of SOX2 Inhibition for Embryonal Carcinoma.
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    • NKX2-1/TITF1/TTF-1-Induced ROR1 is required to sustain EGFR survival signaling in lung adenocarcinoma.
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    • PCA-1/ALKBH3 contributes to pancreatic cancer by supporting apoptotic resistance and angiogenesis.
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      Cancer Res. 2012 Sep 15;72(18):4829-39. PMID:22826605
    • The orphan G protein-coupled receptor GPR55 promotes cancer cell proliferation via ERK.
      Andradas C, Caffarel MM, Pérez-Gómez E, Salazar M, Lorente M, Velasco G, Guzmán M, Sánchez C.
      Oncogene. 2011 Jan 13;30(2):245-52. PMID:20818416 short communication
    • RECQL1 and WRN proteins are potential therapeutic targets in head and neck squamous cell carcinoma.
      Arai A, Chano T, Futami K, Furuichi Y, Ikebuchi K, Inui T, Tameno H, Ochi Y, Shimada T, Hisa Y, Okabe H.
      Cancer Res. 2011 Jul 1;71(13):4598-607. PMID:21571861
    • GEP100-Arf6-AMAP1-cortactin pathway frequently used in cancer invasion is activated by VEGFR2 to promote angiogenesis.
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      PLoS One. 2011;6(8):e23359. PMID:21858086
    • Transient silencing of galectin-3 expression promotes both in vitro and in vivo drug-induced apoptosis of human pancreatic carcinoma cells.
      Kobayashi T, Shimura T, Yajima T, Kubo N, Araki K, Wada W, Tsutsumi S, Suzuki H, Kuwano H, Raz A.
      Clin Exp Metastasis. 2011 Apr;28(4):367-76. PMID:21331750
    • Stimulation of the midkine/ALK axis renders glioma cells resistant to cannabinoid antitumoral action.
      Lorente M, Torres S, Salazar M, Carracedo A, Hernández-Tiedra S, Rodríguez-Fornés F, García-Taboada E, Meléndez B, Mollejo M, Campos-Martín Y, Lakatosh SA, Barcia J, Guzmán M, Velasco G.
      Cell Death Cell Death Differ. 2011 Jun;18(6):959-73. PMID:21233844
    • miR-135b mediates NPM-ALK-driven oncogenicity and renders IL-17-producing immunophenotype to anaplastic large cell lymphoma.
      Matsuyama H, Suzuki HI, Nishimori H, Noguchi M, Yao T, Komatsu N, Mano H, Sugimoto K, Miyazono K.
      Blood. 2011 Dec 22;118(26):6881-92. PMID:22042699
    • ZNF689 suppresses apoptosis of hepatocellular carcinoma cells through the down-regulation of Bcl-2 family members.
      Shigematsu S, Fukuda S, Nakayama H, Inoue H, Hiasa Y, Onji M, Higashiyama S.
      Exp Cell Res. 2011 Aug 1;317(13):1851-9. PMID:21624362
    • The metastasis-associated microRNA miR-516a-3p is a novel therapeutic target for inhibiting peritoneal dissemination of human scirrhous gastric cancer.
      Takei Y, Takigahira M, Mihara K, Tarumi Y, Yanagihara K.
      Cancer Res. 2011 Feb 15;71(4):1442-1453. PMID:21169410
    • Synthetic siRNA targeting the breakpoint of EWS/Fli-1 inhibits growth of Ewing sarcoma xenografts in a mouse model.
      Takigami I, Ohno T, Kitade Y, Hara A, Nagano A, Kawai G, Saitou M, Matsuhashi A, Yamada K, Shimizu K.
      Int J Cancer. 2011 Jan 1;128(1):216-26. PMID:20648560
    • ALKBH3, a human AlkB homologue, contributes to cell survival in human non-small-cell lung cancer.
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