Atelocollagen Microspheres | KOKEN CO., LTD. | KOKEN CO., LTD.

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Atelocollagen Microspheres


Atelocollagen microspheres are microbeads-like atelocollagen scaffold for cell culture. This carrier is useful for culturing adhesive cells such as fibroblasts, epithelial cells and osteoblasts due to its ability to maintain cell functions.

What is Atelocollagen?


    High-density culture


  • Collagen microspheres create an in vitro-like environment because they are produced exclusively from fibril-forming type I atelocollagen.

  • Cells are easily harvested by collagenase treatment.

Types of collagen

Bovine dermis derived atelocollagen

Cat. No. Product Packaging Price

Atelocollagen Microspheres  Sterilized
Surface area: approximately 3,800 cm²/15mL
Size: 100-400μm
Approximately 3 million particles

15 mL/bottle Visit distributor’s
web page

Storage: 2-10℃ (Do not freeze)  For research use only.

Click here for frequently asked questions about Atelocollagen microspheres


  • Bone, Cartilage
  • Miscellaneous
    • Efficacy of bone regeneration using collagen microspheres as scaffold.
      Shunsuke Baba, Naoyuki Matsumoto, Yuki Kaneshita, Kaoru lnami, Hidetoshi Morikuni and Takayoshi Kawazoe.
      J Osaka Dent Univ. 2008. 42(1), 9-15.
    • Mandibular reconstruction using a combination graft of rhBMP-2 with bone marrow cells expanded in vitro.
      Seto I, Marukawa E, Asahina I.
      Plast Reconstr Surg. 2006 Mar;117(3):902-908. PMID: 16525283
    • Propagation of human nasal chondrocytes in microcarrier spinner culture.
      Shikani AH, Fink DJ, Sohrabi A, Phan P, Polotsky A, Hungerford DS, Frondoza CG.
      Am J Rhinol. 2004 Mar-Apr;18(2):105-12. PMID: 15152876
    • The role of osteopontin on calcium oxalate crystal formation.
      Konya E, Umekawa T, Iguchi M, Kurita T.
      Eur Urol. 2003 May;43(5):564-71. PMID: 12706004
    • Collagen microcarrier spinner culture promotes osteoblast proliferation and synthesis of matrix proteins.
      Overstreet M, Sohrabi A, Polotsky A, Hungerford DS, Frondoza CG.
      In Vitro Cell Dev Biol Anim. 2003 May-Jun;39(5-6):228-34. PMID: 14613330
    • The effect of osteopontin immobilized collagen granules in the seed crystal method.
      Umekawa T, Iguchi M, Kurita T.
      Urol Res. 2001 Aug;29(4):282-6. PMID: 11585285
    • Beta-1 integrin expression by human nasal chondrocytes in microcarrier spinner culture.
      Bouchet BY, Colón M, Polotsky A, Shikani AH, Hungerford DS, Frondoza CG.
      J Biomed Mater Res. 2000 Dec 15;52(4):716-24. PMID: 11033555
    • Human chondrocytes proliferate and produce matrix components in microcarrier suspension culture.
      Frondoza C, Sohrabi A, Hungerford D.
      Biomaterials. 1996 May;17(9):879-88. PMID: 8718933
    • Comparative histological studies of bone and cartilage formations induced by various BMP-carrier composites.:Comparative histological studies of bone and cartilage formations induced by various BMP-carrier composites.
      Liliana Missana, Noriyuki Nagai and Yoshinori Kuboki
      Japanese Association for Oral Biology 36(1), 9-19, 1994
    • Cross-linked collagen gel spheres as a useful carrier for cell culture of MC 3T3-E1 clonal osteogenic cells.
      Morimichi Mizuno, Tomoyo Kasagi, Yoshinori Kuboki.
      Japanese J. Oral Biol. 1988 30(6):855-8.
    • Type I collagen can function as a reservoir of basic fibroblast growth factor.
      Kanematsu A, Marui A, Yamamoto S, Ozeki M, Hirano Y, Yamamoto M, Ogawa O, Komeda M, Tabata Y.
      J Control Release. 2004 Sep 30;99(2):281-92. PMID: 15380637
    • Expression of vascular endothelial growth factor promotes colonization, vascularization, and growth of transplanted hepatic t issues in the mouse.
      Ajioka I, Akaike T, Watanabe Y.
      Hepatology. 1999 Feb;29(2):396-402. PMID:9918915
    • Correlation between cell-adherent activity and surface structure in Porphyromonas gingivalis.
      Watanabe K, Yamaji Y, Umemoto T.
      Oral Microbiol Immunol. 1992 Dec;7(6):357-63. PMID: 1363734