Newsletters
Just mix and inject: in vivo transfection reagent AteloGene
31 August 2015
In this edition of the newsletter, we introduce a research paper that uses a unique in vivo transfection reagent, AteloGene Local Use, a product that forms a gel at the site of administration and then slowly releases nucleic acids.
Administration of miR-21/23a/27a inhibitors to xenograft tumour model
Article information
MicroRNAs cooperatively inhibit a network of tumor suppressor genes to promote pancreatic tumor growth and progression.
Frampton AE, Castellano L, Colombo T, Giovannetti E, Krell J, Jacob J, Pellegrino L, Roca-Alonso L, Funel N, Gall TM, De Giorgio A, Pinho FG, Fulci V, Britton DJ, Ahmad R, Habib NA, Coombes RC, Harding V, Knosel T, Stebbing J, Jiao LR.
Gastroenterology. 2014 Jan;146(1):268-77.e18. PMID: 24120476
Overview
In this article, miR-21/23a/27a inhibitors were administered to a xenograft model of pancreatic ductal adenocarcinoma (MIA PaCa-2, PANC-1) using AteloGene Local Use.
A marked tumour growth inhibitory effect was observed in both xenograft tumour models. Stronger effects were apparent in the PANC-1 xenograft model, where tumour size was suppressed approximately 2-fold compared with the control group.
Improvement of AteloGene Local Use yields increased gelation speed at the site of administration and enhanced transfection efficiency
Product name
– AteloGene Local Use “Quick Gelation” (Cat. No.: #1492 for Cosmo Bio custmoers）
(Cat. No.: #1494 for REPROCELL customers)
