局所投与用 AteloGene® Local Use "Quick Gelation" | 株式会社高研

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局所投与用 AteloGene® Local Use “Quick Gelation”

概要

本製品はマウスへの局所投与により siRNA/miRNA を生体組織中へデリバリーし、効率よく細胞内へ導入するためのキットです。
「AteloGene®」の主成分であるアテロコラーゲンは、正に荷電しているため、適切な濃度と割合で核酸と混合することにより、 静電的に複合体を形成します。そして、複合体形成により、核酸分解酵素による核酸の分解を防ぐことが可能です 。

アテロコラーゲンとは

用途

核酸の局所投与

特長

  • 「AteloGene®」の主成分であるアテロコラーゲンは、siRNA/miRNAと複合体を形成するため、RNAi効果が長続きします。
  • 「AteloGene®」はアテロコラーゲンから作られているため、無毒性です。
  • 「AteloGene® Local Use」は生体内でゲル化する性質を持っているため、siRNA/miRNAが投与部位に留まり、徐放効果が得られます。
  • 「AteloGene® Local Use “Quick Gelation”」は投与部位でのゲル形成速度を高めることで、核酸導入効果が向上しています。

キットの内容

①AteloGene® Local Use “Quick Gelation”
プレフィルドシリンジ
(調製中のロスも含めて540μLで5回投与分)
540 μL入り × 3 本
②QGバッファー 2.5 mL × 1 本
③2mLマイクロチューブ 4本 (予備のチューブ1本を含む)
④18G注射針 8本 (予備の針2本を含む)
⑤取扱説明書 1冊

キット以外に必要な機器・試薬

  • 1mLディスポーザブルシリンジ
  • 27G注射針
  • siRNA/miRNA(AteloSiLence in vivo 用siRNA/miRNAのようなPAGE精製またはHPLC精製グレード)
  • siRNA/miRNA調製用容器(滅菌済み、RNase free)
  • 保冷具(クラッシュアイス、コールドブロックなど)
  • ローテーター(転倒攪拌できるもの、TAITEC RT-5、Bibby scientific SB3など)
  • ピペッターおよびチップ(滅菌済み、RNase free)
  • 高速冷却遠心機
  • 麻酔薬

保管方法:冷蔵(2〜10℃)

製品番号 製品 包装 価格(税別)
#1490 AteloGene® Local Use “Quick Gelation” 1キット(15回投与分※) ¥ 75,000

本品は研究用試薬です。

※200μL/回として算出しているため、対象組織によっては10回以上使用可能な場合もあります。

使用例

【AteloGene® Local Use “Quick Gelation”を用いたマウス皮下腫瘍モデルへのsiRNA局所投与】

マウス皮下に移植したデュアルルシフェラーゼ発現メラノーマ細胞に対し、「AteloGene® Local Use “QuickGelation”(QG)」を使用してルシフェラーゼsiRNA(Luc siRNA)を局所投与すると、顕著なルシフェラーゼ発現抑制効果が認められた。

参考文献

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